EC-1456 | CAS# 1602487-16-0

MedKoo Cat#: 413987 | Name: EC-1456

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EC-1456 is an injectable small molecule drug conjugate composed of folate/folic acid (vitamin B9) bound to the anti-mitotic compound tubulysin B hydrazide.

Chemical Structure

EC-1456

CAS#1602487-16-0

Theoretical Analysis

MedKoo Cat#: 413987

Name: EC-1456

CAS#: 1602487-16-0

Chemical Formula: C112H169N23O44S3

Exact Mass: 2636.0856

Molecular Weight: 2637.88

Elemental Analysis: C, 51.00; H, 6.46; N, 12.21; O, 26.69; S, 3.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

EC-1456; EC 1456; EC1456

IUPAC/Chemical Name

CC[C@H](C)[C@H](NC(=O)[C@H]1CCCCN1C)C(=O)N(COC(=O)CC(C)C)[C@H](C[C@@H](OC(=O)C)c2nc(cs2)C(=O)N[C@H](C[C@H](C)C(=O)NNC(=O)OCCSSC[C@@H](NC(=O)[C@H](CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)NC(=O)CC[C@@H](NC(=O)c3ccc(NCc4cnc5NC(=NC(=O)c5n4)N)cc3)C(=O)O)C(=O)O)Cc6ccc(O)cc6)C(C)C

InChi Key

VQYQFGJBFMQBOZ-BSZXITTFSA-N

InChi Code

InChI=1S/C112H169N23O44S3/c1-11-55(6)89(129-105(169)73-14-12-13-35-134(73)10)108(171)135(52-178-88(155)38-53(2)3)74(54(4)5)41-81(179-58(9)139)107-128-71(50-180-107)104(168)120-62(40-59-15-21-64(140)22-16-59)39-56(7)97(161)132-133-112(176)177-36-37-181-182-51-72(110(174)175)127-103(167)67(25-31-84(149)117-46-77(143)93(158)95(160)80(146)49-138)123-102(166)69(28-34-87(153)154)125-100(164)66(24-30-83(148)116-45-76(142)92(157)94(159)79(145)48-137)122-101(165)68(27-33-86(151)152)124-99(163)65(23-29-82(147)115-44-75(141)91(156)57(8)78(144)47-136)121-85(150)32-26-70(109(172)173)126-98(162)60-17-19-61(20-18-60)114-42-63-43-118-96-90(119-63)106(170)131-111(113)130-96/h15-22,43,50,53-57,62,65-70,72-81,89,91-95,114,136-138,140-146,156-160H,11-14,23-42,44-49,51-52H2,1-10H3,(H,115,147)(H,116,148)(H,117,149)(H,120,168)(H,121,150)(H,122,165)(H,123,166)(H,124,163)(H,125,164)(H,126,162)(H,127,167)(H,129,169)(H,132,161)(H,133,176)(H,151,152)(H,153,154)(H,172,173)(H,174,175)(H3,113,118,130,131,170)/t55-,56-,57+,62+,65-,66-,67-,68+,69+,70+,72+,73+,74+,75-,76-,77-,78+,79+,80+,81+,89-,91-,92+,93+,94+,95+/m0/s1

SMILES Code

CC[C@@H]([C@@H](C(N([C@@H](C(C)C)C[C@H](c1scc(C(N[C@@H](Cc2ccc(O)cc2)C[C@@H](C(NNC(OCCSSC[C@H](C(O)=O)NC([C@@H](NC([C@H](NC([C@@H](NC([C@H](NC([C@@H](NC(CC[C@H](C(O)=O)NC(c3ccc(NCc4nc5c(NC(N)=NC5=O)nc4)cc3)=O)=O)CCC(NC[C@@H]([C@H]([C@@H]([C@@H](CO)O)C)O)O)=O)=O)CCC(O)=O)=O)CCC(NC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)=O)=O)CCC(O)=O)=O)CCC(NC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)=O)=O)=O)=O)C)=O)n1)OC(C)=O)COC(CC(C)C)=O)=O)NC([C@H]6CCCCN6C)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 2,637.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Duparc-Alegria N, Tiberghien K, Abdoul H, Dahmani S, Alberti C, Thiollier AF. Assessment of a short hypnosis in a paediatric operating room in reducing postoperative pain and anxiety: A randomised study. J Clin Nurs. 2018 Jan;27(1-2):86-91. doi: 10.1111/jocn.13848. Epub 2017 Jul 4. PMID: 28403569.