CTX-0294885 is a novel broad-spectrum kinase inhibitor. CTX-0294885 exhibits inhibitory activity against a broad range of kinases in vitro. Use of a quantitative proteomics approach confirmed the selectivity of CTx - 0294885 -bound beads for kinase enrichment. Large-scale CTX- 0294885 -based affinity purification followed by LC-MS/MS led to the identification of 235 protein kinases from MDA-MB-231 cells, including all members of the AKT family that had not been previously detected by other broad-spectrum kinase inhibitors. CTX- 0294885 represents a powerful new reagent for analysis of kinome signaling networks that may facilitate development of targeted therapeutic strategies.
MedKoo Cat#: 406457
Name: CTX-0294885
CAS#: 1439934-41-4
Chemical Formula: C22H24ClN7O
Exact Mass: 437.1731
Molecular Weight: 437.93
Elemental Analysis: C, 60.34; H, 5.52; Cl, 8.10; N, 22.39; O, 3.65
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 60.0 | 137.01 | |
| DMSO | 20.0 | 45.67 | |
| DMSO:PBS (pH 7.2) (1:1) | 0.5 | 1.14 | |
| Ethanol | 0.1 | 0.23 |
The following data is based on the product molecular weight 437.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
