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MedKoo Cat#: 413964 | Name: DuP 734

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DuP 734 is a sigma receptor antagonist. DuP 734 is a selective and potent sigma and 5-HT2 receptor ligand with weak affinity for D2 receptors. DuP 734 may have antipsychotic activity without the liability of motor side effects typical of neuroleptics.

Chemical Structure

DuP 734
DuP 734
CAS#135135-87-4

Theoretical Analysis

MedKoo Cat#: 413964

Name: DuP 734

CAS#: 135135-87-4

Chemical Formula: C17H23BrFNO

Exact Mass: 355.0947

Molecular Weight: 356.28

Elemental Analysis: C, 57.31; H, 6.51; Br, 22.43; F, 5.33; N, 3.93; O, 4.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DuP 734; Dup-734; Dup734
IUPAC/Chemical Name
Ethanone, 2-(1-(cyclopropylmethyl)-4-piperidinyl)-1-(4-fluorophenyl)-, hydrobromide
InChi Key
QLZIAKMYJFJBKA-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H22FNO.BrH/c18-16-5-3-15(4-6-16)17(20)11-13-7-9-19(10-8-13)12-14-1-2-14;/h3-6,13-14H,1-2,7-12H2;1H
SMILES Code
FC1=CC=C(C(CC2CCN(CC3CC3)CC2)=O)C=C1.[H]Br
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 356.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cook L, Tam SW, Rohrbach KW. DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'- oxoethyl)piperidine HBr], a potential antipsychotic agent: preclinical behavioral effects. J Pharmacol Exp Ther. 1992 Dec;263(3):1159-66. PMID: 1361571. 2: Tam SW, Steinfels GF, Gilligan PJ, Schmidt WK, Cook L. DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'-oxoethyl)- piperidine HBr], a sigma and 5-hydroxytryptamine2 receptor antagonist: receptor-binding, electrophysiological and neuropharmacological profiles. J Pharmacol Exp Ther. 1992 Dec;263(3):1167-74. PMID: 1361572. 3: Cheng KT. 1(trans-[123I]Iodopropen-2-yl)-4-[(4-cyanophenoxy )methyl]piperidine. 2007 Jan 5 [updated 2008 Jun 2]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641515. 4: Culp SG, Rominger D, Tam SW, De Souza EB. [3H]DuP 734 [1-(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'- oxoethyl)-piperidine HBr]: a receptor binding profile of a high-affinity novel sigma receptor ligand in guinea pig brain. J Pharmacol Exp Ther. 1992 Dec;263(3):1175-87. PMID: 1361573. 5: Heroux JA, Tam SW, De Souza EB. Autoradiographic identification and characterization of sigma receptors in guinea pig brain using [3H]1(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'-oxoethyl) piperidine ([3H]DuP 734), a novel sigma receptor ligand. Brain Res. 1992 Dec 11;598(1-2):76-86. doi: 10.1016/0006-8993(92)90170-e. PMID: 1486505. 6: Kapil RP, Lam GN. Dose and species dependent pharmacokinetics of a novel sigma receptor antagonist, DuP 734. Res Commun Mol Pathol Pharmacol. 1995 Apr;88(1):3-20. PMID: 7620836. 7: Watanabe M, Rominger D, Hurt SD, De Souza EB, Tam SW. [3H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) piperidine HBr (DuP 734). A selective ligand for sigma receptors in mouse brain in vivo. J Pharmacol Exp Ther. 1993 Sep;266(3):1541-8. PMID: 8371156. 8: Volz HP, Stoll KD. Clinical trials with sigma ligands. Pharmacopsychiatry. 2004 Nov;37 Suppl 3:S214-20. doi: 10.1055/s-2004-832680. PMID: 15547788. 9: Maslov LN, Lishmanov IuB, Rebrova TIu, Gilligan P, Tam SW. Ispol'zovane antagonista del'ta-retseptorov DuP 734 dlia korrektsii sokratitel'noĭ diastolicheskoĭ disfunktsii serdtsa v usloviiakh reperfuzionnogo povrezhdeniia i okislitel'nogo stressa [The use of delta-receptor antagonist DuP 734 for correction of the contractile diastolic cardiac dysfunction in reperfusion injury and oxidative stress]. Eksp Klin Farmakol. 2000 Sep-Oct;63(5):27-30. Russian. PMID: 11109521. 10: Maslov LN, Krylatov AV, Lishmanov IuB. Antiaritmicheskiĭ éffekt selektivnogo antagonista sigma-retseptorov DuP734 [1-(tsiklopropilmetil)-4-(2'-(4''-fluorofenil)-2'-oksoétil)piperidin HBr] [The anti-arrhythmic effect of the selective sigma-receptor antagonist DuP 734 [1-(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'-oxoethyl)piper idine HBr]]. Eksp Klin Farmakol. 1997 Mar-Apr;60(2):24-6. Russian. PMID: 9206562.