Synonym
Secoverine; DU23849; DU-23849; DU 23849
IUPAC/Chemical Name
1-Butanone, 1-cyclohexyl-4-(ethyl(2-(4-methoxyphenyl)-1-methylethyl)amino)-
InChi Key
WAVYHSURRZBQKO-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H35NO2/c1-4-23(16-8-11-22(24)20-9-6-5-7-10-20)18(2)17-19-12-14-21(25-3)15-13-19/h12-15,18,20H,4-11,16-17H2,1-3H3
SMILES Code
O=C(C1CCCCC1)CCCN(CC)C(C)CC2=CC=C(OC)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
345.53
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Brunner F, Waelbroeck M, Christophe J. Secoverine is a non-selective muscarinic antagonist on rat heart and brain receptors. Eur J Pharmacol. 1986 Aug 7;127(1-2):17-25. doi: 10.1016/0014-2999(86)90201-3. PMID: 3758175.
2: Davison JS, Greenwood B, Najafi-Farashah A, Read NW. The effects of atropine and secoverine on gastric secretion and motility in the mouse isolated stomach. Br J Pharmacol. 1983 Jun;79(2):525-9. doi: 10.1111/j.1476-5381.1983.tb11027.x. PMID: 6652343; PMCID: PMC2044866.
3: Zwagemakers JM, Claassen V. Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 1: Antimuscarinic and spasmolytic effects. Arzneimittelforschung. 1980;30(9):1517-26. PMID: 7193020.
4: Greenwood B, Read NW, Hardcastle PT, Hardcastle J. Effect of secoverine and atropine on intestinal secretion and motor activity in the rat small intestine in-vivo. J Pharm Pharmacol. 1984 Feb;36(2):100-6. doi: 10.1111/j.2042-7158.1984.tb03002.x. PMID: 6143792.
5: Ehsanullah M, Lee DA, Williams T, Pollard P, Gazzard B. The effect of secoverine hydrochloride on stimulated sigmoid motility: a double-blind, placebo controlled cross-over study in irritable bowel syndrome. Br J Clin Pharmacol. 1985 Mar;19(3):301-5. doi: 10.1111/j.1365-2125.1985.tb02647.x. PMID: 3986085; PMCID: PMC1463735.
6: Zwagemakers JM, Claassen V. Secoverine selectively antagonizes muscarinic effects in various in vivo preparations. Eur J Pharmacol. 1981 Apr 24;71(1):165-8. doi: 10.1016/0014-2999(81)90403-9. PMID: 7238585.
7: Zwagemakers JM, Claassen V. Pharmacology of secoverine, a new spasmolytic agent with specific antimuscarinic properties. Part 2: General pharmacological properties. Arzneimittelforschung. 1980;30(9):1526-34. PMID: 7193021.
8: Suchowiecky M, Clarke DD, Bhasker M, Perry RJ, Snape WJ Jr. Effect of secoverine on colonic myoelectric activity in diverticular disease of the colon. Dig Dis Sci. 1987 Aug;32(8):833-40. doi: 10.1007/BF01296705. PMID: 3608731.
9: Ammassari-Teule M, Castellano C, Sansone M. Enhancement by oxiracetam of passive avoidance improvement induced by the presynaptic muscarinic antagonist secoverine in mice. Behav Brain Res. 1992 Mar 15;47(1):93-5. doi: 10.1016/s0166-4328(05)80256-6. PMID: 1571105.
10: Marchi M, Raiteri M. Differential antagonism by dicyclomine, pirenzepine and secoverine at muscarinic receptor subtypes in the rat frontal cortex. Eur J Pharmacol. 1985 Jan 2;107(2):287-8. doi: 10.1016/0014-2999(85)90074-3. PMID: 3838514.
