Loperamide is a long-acting synthetic antidiarrheal. It is not significantly absorbed from the gut and has no effect on the adrenergic system or central nervous system. Loperamide may antagonize histamine and interfere with acetylcholine release locally.
MedKoo Cat#: 576723
Name: Loperamide
CAS#: 53179-11-6
Chemical Formula: C29H33ClN2O2
Exact Mass: 476.2231
Molecular Weight: 477.05
Elemental Analysis: C, 73.02; H, 6.97; Cl, 7.43; N, 5.87; O, 6.71
The following data is based on the product molecular weight 477.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
