DS 4574 | CAS# 118314-35-5 | peptidoleukotriene receptor antagonist

MedKoo Cat#: 413940 | Name: DS 4574

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DS 4574 is a peptidoleukotriene receptor antagonist used in treatment of hypersensitivity.

Chemical Structure

DS 4574

CAS#118314-35-5

Theoretical Analysis

MedKoo Cat#: 413940

Name: DS 4574

CAS#: 118314-35-5

Chemical Formula: C13H16N6OS

Exact Mass: 304.1106

Molecular Weight: 304.37

Elemental Analysis: C, 51.30; H, 5.30; N, 27.61; O, 5.26; S, 10.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DS 4574; DS4574; DS 4574

IUPAC/Chemical Name

(1,3,4)Thiadiazolo(3,2-a)-1,2,3-triazolo(4,5-d)pyrimidin-9(1H)-one, 6-(2-cyclohexylethyl)-

InChi Key

ASIFEXZWAKYMRM-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H16N6OS/c20-12-10-11(16-18-15-10)14-13-19(12)17-9(21-13)7-6-8-4-2-1-3-5-8/h8H,1-7H2,(H,15,16,18)

SMILES Code

O=C1C(NN=N2)=C2N=C3N1N=C(CCC4CCCCC4)S3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 304.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Aibara S, Mori M, Iwamoto T, Chiba T, Tsukada W. Antagonistic action of DS-4574 against leukotrienes in guinea-pig smooth muscle. Arch Int Pharmacodyn Ther. 1991 Nov-Dec;314:147-59. PMID: 1668601. 2: Aibara S, Mori M, Tsukada W. Inhibitory effect of DS-4574 on leukotriene- or antigen-induced bronchoconstriction in guinea pigs. Int Arch Allergy Immunol. 1993;100(3):268-73. doi: 10.1159/000236423. PMID: 7680929. 3: Tabuchi Y, Kurebayashi Y. Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats. Jpn J Pharmacol. 1992 Dec;60(4):335-40. doi: 10.1254/jjp.60.335. PMID: 1287268. 4: Aibara S, Mori M, Iwamoto T, Tsubokawa M, Takamori H, Tsukada W. Effects of DS-4574, a new orally active antiallergic agent, in experimental allergic and inflammatory models. Jpn J Pharmacol. 1993 Apr;61(4):267-76. doi: 10.1254/jjp.61.267. PMID: 8320873. 5: Tabuchi Y, Kawarabayashi K, Furuhama K. Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats. Agents Actions. 1994 Mar;41(1-2):21-4. doi: 10.1007/BF01986388. PMID: 7521568. 6: Yamashika Y, Tabuchi Y, Kokue E. Antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on gastric acid secretion in the pig. Agents Actions. 1994 Mar;41(1-2):17-20. doi: 10.1007/BF01986387. PMID: 8079817. 7: Tabuchi Y, Furuhama K. Inhibitory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene receptor antagonism, on gastric acid secretion in rats. Eur J Pharmacol. 1994 Apr 1;255(1-3):229-34. doi: 10.1016/0014-2999(94)90102-3. PMID: 8026547. 8: Aibara S, Mori M, Tsubokawa M, Iwamoto T, Tsukada W. Antiallergic activity of 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo- [3,2-a]-1,2,3-triazolo-[4,5-d]pyrimidin-9(3H)-one (DS-4574) in rats. Int Arch Allergy Immunol. 1992;98(2):146-52. doi: 10.1159/000236178. PMID: 1379506. 9: Tabuchi Y, Kawarabayashi K, Komada T, Furuhama K. Protective effect of DS-4574 on gastric mucosal injury induced by acidified ethanol in rats. Eur J Pharmacol. 1993 Nov 30;250(1):197-9. doi: 10.1016/0014-2999(93)90644-w. PMID: 7907021. 10: Murayama N, Nakaoka M, Nomura H, Hakusui H. Radioimmunoassay for DS-4574, an antiallergic agent: development, evaluation, and application to human plasma samples. J Pharm Sci. 1994 Nov;83(11):1574-7. doi: 10.1002/jps.2600831111. PMID: 7891277.