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MedKoo Cat#: 413925 | Name: DRL-17822

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DRL-17822 is a Cholesteryl Ester Transfer Protein (CETP) inhibitor.

Chemical Structure

DRL-17822
DRL-17822
CAS#898911-09-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 413925

Name: DRL-17822

CAS#: 898911-09-6 (HCl)

Chemical Formula: C30H31F6N7

Exact Mass: 603.2545

Molecular Weight: 603.62

Elemental Analysis: C, 59.70; H, 5.18; F, 18.88; N, 16.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DRL-17822; DRL17822; DRL 17822
IUPAC/Chemical Name
3-(((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)methyl)-N,N-bis(cyclopropylmethyl)-8-methylquinolin-2-amine
InChi Key
OCNBSSLDAIWTKS-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H31F6N7/c1-18-4-3-5-22-12-23(27(37-26(18)22)42(14-19-6-7-19)15-20-8-9-20)17-43(28-38-40-41(2)39-28)16-21-10-24(29(31,32)33)13-25(11-21)30(34,35)36/h3-5,10-13,19-20H,6-9,14-17H2,1-2H3
SMILES Code
CC1=C2N=C(N(CC3CC3)CC4CC4)C(CN(CC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)C6=NN(C)N=N6)=CC2=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 603.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kruithof AC, Kumar R, Stevens J, de Kam ML, Gautam A, Alikunju S, Padhi BK, Kulkarni S, Raghuvanshi RS, Gandhi R, Burggraaf J, Kamerling IMC. Effect of Food on the Pharmacokinetics of 2 Formulations of DRL-17822, a Novel Selective Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Healthy Males. Clin Pharmacol Drug Dev. 2019 Nov;8(8):1042-1052. doi: 10.1002/cpdd.707. Epub 2019 Jun 10. PMID: 31183985. 2: Goulooze SC, Kruithof AC, Alikunju S, Gautam A, Burggraaf J, Kamerling IMC, Stevens J. The effect of food and formulation on the population pharmacokinetics of cholesteryl ester transferase protein inhibitor DRL-17822 in healthy male volunteers. Br J Clin Pharmacol. 2020 Oct;86(10):2095-2101. doi: 10.1111/bcp.14297. Epub 2020 Apr 20. PMID: 32250455; PMCID: PMC7495284. 3: Mousa SS, Block RC, Mousa SA. High Density Lipoprotein (HDL) Modulation Targets. Drugs Future. 2010 Jan;35(1):33-39. doi: 10.1358/dof.2010.035.01.1452012. PMID: 22740724; PMCID: PMC3381456.