IUPAC/Chemical Name
(5aS,9aS,9bR)-6,6,9a-trimethyl-5,5a,6,7,8,9,9a,9b-octahydronaphtho[1,2-c]furan-1(3H)-one
InChi Key
BQNSBENKJCLJGN-ZOWXZIJZSA-N
InChi Code
InChI=1S/C15H22O2/c1-14(2)7-4-8-15(3)11(14)6-5-10-9-17-13(16)12(10)15/h5,11-12H,4,6-9H2,1-3H3/t11-,12+,15-/m0/s1
SMILES Code
CC1(CCC[C@]2([C@H]1CC=C3COC([C@H]23)=O)C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
234.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Prinsloo G, Marokane CK, Street RA. Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research. J Ethnopharmacol. 2018 Jan 10;210:133-155. doi: 10.1016/j.jep.2017.08.005. Epub 2017 Aug 12. PMID: 28807850; PMCID: PMC7125770.
2: Arias HR, Feuerbach D, Schmidt B, Heydenreich M, Paz C, Ortells MO. Drimane Sesquiterpenoids Noncompetitively Inhibit Human α4β2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human α3β4 and α7 Subtypes. J Nat Prod. 2018 Apr 27;81(4):811-817. doi: 10.1021/acs.jnatprod.7b00893. Epub 2018 Apr 10. PMID: 29634269.
3: Paz C, Viscardi S, Iturra A, Marin V, Miranda F, Barra PJ, Mendez I, Duran P. Antifungal Effects of Drimane Sesquiterpenoids Isolated from Drimys winteri against Gaeumannomyces graminis var. tritici. Appl Environ Microbiol. 2020 Nov 24;86(24):e01834-20. doi: 10.1128/AEM.01834-20. PMID: 33036992; PMCID: PMC7688224.
4: Allouche N, Apel C, Martin MT, Dumontet V, Guéritte F, Litaudon M. Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest. Phytochemistry. 2009 Mar;70(4):546-53. doi: 10.1016/j.phytochem.2009.01.012. Epub 2009 Feb 27. PMID: 19251287.
5: Harrigan GG, Ahmad A, Baj N, Glass TE, Gunatilaka AA, Kingston DG. Bioactive and other sesquiterpenoids from Porella cordeana. J Nat Prod. 1993 Jun;56(6):921-5. doi: 10.1021/np50096a016. PMID: 8350093.
6: Rukachaisirikul V, Khamthong N, Sukpondma Y, Phongpaichit S, Hutadilok- Towatana N, Graidist P, Sakayaroj J, Kirtikara K. Cyclohexene, diketopiperazine, lactone and phenol derivatives from the sea fan-derived fungi Nigrospora sp. PSU-F11 and PSU-F12. Arch Pharm Res. 2010 Mar;33(3):375-80. doi: 10.1007/s12272-010-0305-3. Epub 2010 Mar 30. PMID: 20361301.
7: Socolsky C, Muruaga N, Bardón A. Drimanes and other terpenoids from the fern Thelypteris hispidula (Decne.) Reed. Chem Biodivers. 2005 Aug;2(8):1105-8. doi: 10.1002/cbdv.200590079. PMID: 17193193.
