IUPAC/Chemical Name
N-(3,9-Dimethyl-endo-3,9-diazabicyclo(3.3.1)non-7-yl)-1H-indazole-3-carboxamide
InChi Key
MHNNVDILNTUWNS-XYYAHUGASA-N
InChi Code
InChI=1S/C17H23N5O/c1-21-9-12-7-11(8-13(10-21)22(12)2)18-17(23)16-14-5-3-4-6-15(14)19-20-16/h3-6,11-13H,7-10H2,1-2H3,(H,18,23)(H,19,20)/t11-,12-,13+
SMILES Code
CN1C[C@H]2C[C@H](C[C@@H](C1)N2C)NC(=O)c3n[nH]c4ccccc34
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
313.40
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tsukagoshi S; Tokyo Cooperative Oncology Group. [Introduction of novel anti-emetic agent, indisetron hydrochloride, developed recently in Japan]. Gan To Kagaku Ryoho. 2005 Apr;32(4):567-73. Review. Japanese. PubMed PMID: 15853230.
2: Iritani E, Isono K, Izumo T, Takeda N, Kanemura T, Tamaoki J, Nagai A. [The efficacy of indisetron hydrochloride for the management of chemotherapy-induced nausea and vomiting for lung cancer]. Gan To Kagaku Ryoho. 2009 Sep;36(9):1489-92. Japanese. PubMed PMID: 19755818.
3: Kanbe M, Osada M. [CPT-11-induced diarrhea treated with indisetron hydrochloride--a case report]. Gan To Kagaku Ryoho. 2005 Dec;32(13):2145-7. Japanese. PubMed PMID: 16352947.
4: Nakatsumi H, Komatsu Y, Yuki S, Sogabe S, Tateyama M, Muto S, Kudo M, Kato K, Miyagishima T, Uebayashi M, Meguro T, Oba K, Asaka M. Optimal dose period for indisetron tablets for preventing chemotherapy-induced nausea and vomiting with modified FOLFOX6: a randomized pilot study. Chemotherapy. 2012;58(6):439-44. doi: 10.1159/000345920. Epub 2013 Jan 29. PubMed PMID: 23364217.
5: Sharma A, Sonah H, Deshmukh RK, Gupta NK, Singh NK, Sharma TR. Analysis of genetic diversity in earthworms using DNA markers. Zoolog Sci. 2011 Jan;28(1):25-31. doi: 10.2108/zsj.28.25. PubMed PMID: 21186943.
