MedKoo Cat#: 576670 | Name: Indenolol hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Indenolol hydrochloride is a beta-adrenergic blocker.

Chemical Structure

Indenolol hydrochloride
Indenolol hydrochloride
CAS#81789-85-7

Theoretical Analysis

MedKoo Cat#: 576670

Name: Indenolol hydrochloride

CAS#: 81789-85-7

Chemical Formula: C15H22ClNO2

Exact Mass: 283.1339

Molecular Weight: 283.80

Elemental Analysis: C, 63.48; H, 7.81; Cl, 12.49; N, 4.94; O, 11.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Indenolol hydrochloride; Indenolol HCl
IUPAC/Chemical Name
1-((1H-inden-4-yl)oxy)-3-(isopropylamino)propan-2-ol hydrochloride
InChi Key
LQUALIUFEGJTKA-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H21NO2.ClH/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15;/h3-4,6-8,11,13,16-17H,5,9-10H2,1-2H3;1H
SMILES Code
Cl.CC(C)NCC(O)COc1cccc2CC=Cc12
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 283.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Al-Othman ZA, Al-Warthan A, Alam SD, Ali I. Enantio-separation of drugs with multiple chiral centers by chromatography and capillary electrophoresis. Biomed Chromatogr. 2014 Nov;28(11):1514-24. doi: 10.1002/bmc.3259. Epub 2014 Jul 28. Review. PubMed PMID: 25067822. 2: Zhi Y, Yang J, Tian S, Yuan F, Liu Y, Zhang Y, Sun P, Song B, Chen Z. Quantitative structure-activity relationship studies on indenoisoquinoline topoisomerase I inhibitors as anticancer agents in human renal cell carcinoma cell line SN12C. Int J Mol Sci. 2012;13(5):6009-25. doi: 10.3390/ijms13056009. Epub 2012 May 18. PubMed PMID: 22754346; PubMed Central PMCID: PMC3382809. 3: Opina AC, Wu Y, Zhao P, Kiefer G, Sherry AD. The pH sensitivity of -NH exchange in LnDOTA-tetraamide complexes varies with amide substituent. Contrast Media Mol Imaging. 2011 Nov-Dec;6(6):459-64. doi: 10.1002/cmmi.445. PubMed PMID: 22144023; PubMed Central PMCID: PMC3233223. 4: Zhang X, Teo WT, Chan PW. Ytterbium(III) triflate catalyzed tandem Friedel-Crafts alkylation/hydroarylation of propargylic alcohols with phenols as an expedient route to indenols. Org Lett. 2009 Nov 5;11(21):4990-3. doi: 10.1021/ol901981s. PubMed PMID: 19863152. 5: Ali I, Saleem K, Gaitonde VD, Aboul-Enein HY, Hussain I. Chiral separations of some beta-adrenergic agonists and antagonists on AmyCoat column by HPLC. Chirality. 2010 Jan;22(1):24-8. doi: 10.1002/chir.20697. PubMed PMID: 19208401. 6: Ali I, Gaitonde VD, Aboul-Enein HY, Hussain A. Chiral separation of beta-adrenergic blockers on CelluCoat column by HPLC. Talanta. 2009 Apr 30;78(2):458-63. doi: 10.1016/j.talanta.2008.11.043. Epub 2008 Dec 6. PubMed PMID: 19203609. 7: Almotrefi AA, Basco C, Moorji A, Dzimiri N. Evidence for the binding of beta-adrenoceptor blockers to microsomal Na+/K+-ATPase in guinea pig heart preparations. Can J Physiol Pharmacol. 2001 Jan;79(1):8-12. PubMed PMID: 11201505. 8: Poggesi L, Bisi G, La Cava G, Sciagra R, Del Rosso A, Masotti G. Renal and limb vasodilatation during acute beta-adrenoceptor blockade with indenolol. J Clin Pharmacol. 1995 Feb;35(2):176-81. PubMed PMID: 7751429. 9: Sau F, Seguro C, Pargentino E. [Chronology of regression of hypertensive ventricular hypertrophy during antihypertensive therapy with beta blockers]. Cardiologia. 1994 Jul;39(7):473-9. Italian. PubMed PMID: 7982244. 10: Almotrefi AA, Dzimiri N. Effects of beta-adrenoceptor blockers on mitochondrial ATPase activity in guinea pig heart preparations. Eur J Pharmacol. 1992 May 14;215(2-3):231-6. PubMed PMID: 1356792. 11: Wadworth AN, Murdoch D, Brogden RN. Atenolol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders. Drugs. 1991 Sep;42(3):468-510. Review. PubMed PMID: 1720383. 12: al-Angary AA, el-Sayed YM, al-Meshal MA, al-Dardiri MM, Mahrous GM. A sensitive high-performance liquid chromatographic analysis of propranolol in serum. J Clin Pharm Ther. 1991 Apr;16(2):93-101. PubMed PMID: 1856255. 13: Almotrefi AA, Dzimiri N. Effects of beta-adrenergic blockers on Na(+)-K(+)-ATPase activity in guinea-pig heart preparations: comparison with ouabain. Arch Int Pharmacodyn Ther. 1991 Mar-Apr;310:94-101. PubMed PMID: 1685314. 14: Sau F, Seguro C, Pili G, Basciu M, Siddi PP, Tamponi R, Cherchi A. [Electrocardiographic and echocardiographic changes during antihypertensive therapy]. Cardiologia. 1990 Dec;35(12):1015-22. Italian. PubMed PMID: 2151370. 15: Sau F, Seguro C, Lai C, Orani E, Soro A, Onnis E, Cherchi A. [Effects of indenolol on left ventricular mass in patients with essential arterial hypertension]. Cardiologia. 1990 Nov;35(11):925-30. Italian. PubMed PMID: 2151570. 16: Ambrosioni E, Birkenhäger W, De Leeuw PW, Dal Palù C, Demanet JC, Groothold G, Libretti A, Mailland F, Malacco E, Poli A, et al. Comparison of a vasodilating beta-blocker and a cardioselective beta-blocker in long-term treatment of hypertension: a European multicentre study. J Hypertens Suppl. 1989 Dec;7(6):S266-7. PubMed PMID: 2576667. 17: Taddei S, Pedrinelli R, Salvetti A. Indenolol, a beta-blocker with partial agonism at vascular beta-adrenoceptors. Clin Pharmacol Ther. 1989 Nov;46(5):560-5. PubMed PMID: 2573443. 18: Munari L, Milanesi I, Silvani A, Bussone G, Boiardi A. Pharmacologic evaluation of cardiovascular reflex responses in migraine patients: lack of central sympathetic modulation? Funct Neurol. 1989 Oct-Dec;4(4):375-8. PubMed PMID: 2620855. 19: Almotrefi AA, Aboul-Enein HY, Premkumar LS. Evaluation of the antifibrillatory activity of fluorinated derivatives of indenolol and nadolol in isolated rabbit and rat hearts: comparison with propranolol. Arch Int Pharmacodyn Ther. 1989 Sep-Oct;301:122-30. PubMed PMID: 2576192. 20: Yamada K, Matsumoto S, Nagashima M, Kumagai M, Kimura H, Furukawa T. Involvement of central beta-adrenoceptors in the regulation of yawning responses. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):26-30. PubMed PMID: 2571945.