MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 413902 | Name: Dosulepin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dosulepin is a tricyclic antidepressant with some tranquilizing action.

Chemical Structure

Dosulepin
Dosulepin
CAS#113-53-1

Theoretical Analysis

MedKoo Cat#: 413902

Name: Dosulepin

CAS#: 113-53-1

Chemical Formula: C19H21NS

Exact Mass: 295.1395

Molecular Weight: 295.44

Elemental Analysis: C, 77.24; H, 7.16; N, 4.74; S, 10.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Dosulepin; HSDB 7181; HSDB 7181; HSDB 7181
IUPAC/Chemical Name
1-Propanamine, 3-dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl- (9CI)
InChi Key
InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/b17-11+
InChi Code
InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/b17-11+
SMILES Code
CN(C)CC/C=C1C2=CC=CC=C2SCC3=CC=CC=C/13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 295.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Elama HS, Elsebaei FA, Ali FAA, El-Brashy AM. Validated spectrophotometric and spectrofluorimetric methods for determination of dapoxetine hydrochloride and dosulepin hydrochloride in their dosage forms using mercurochrome. Luminescence. 2018 Dec;33(8):1306-1313. doi: 10.1002/bio.3566. Epub 2018 Oct 30. PMID: 30378237. 2: Mishra BR, Maiti R, Nath S, Sahoo P, Jena M, Mishra A. Effect of Sertraline, Dosulepin, and Venlafaxine on Non-BDNF Neurotrophins in Patients With Depression: A Cohort Study. J Clin Psychopharmacol. 2019 May/Jun;39(3):220-225. doi: 10.1097/JCP.0000000000001022. PMID: 30932945. 3: Hayasaka Y, Purgato M, Magni LR, Ogawa Y, Takeshima N, Cipriani A, Barbui C, Leucht S, Furukawa TA. Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials. J Affect Disord. 2015 Jul 15;180:179-84. doi: 10.1016/j.jad.2015.03.021. Epub 2015 Mar 31. PMID: 25911132. 4: Deslandes PN, Jenkins KS, Haines KE, Hutchings S, Cannings-John R, Lewis TL, Bracchi RC, Routledge PA. A change in the trend in dosulepin usage following the introduction of a prescribing indicator but not after two national safety warnings. J Clin Pharm Ther. 2016 Apr;41(2):224-8. doi: 10.1111/jcpt.12376. Epub 2016 Mar 2. PMID: 26936206. 5: Kittnar O, Paclt I, Mlcek M, Slavícek J, Dohnalová A, Havránek S, Brizman E, Kitzlerová E, Pisvejcová K. QT dispersion and electrical heart field morphology in patients treated with dosulepin. Physiol Res. 2004;53(4):379-86. PMID: 15311996. 6: Danilov DS. 70-letniaia istoriia tritsiklicheskikh antidepressantov [A 70-year history of tricyclic antidepressants]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(12):115-123. Russian. doi: 10.17116/jnevro2019119121115. PMID: 31994524. 7: Shibanoki S, Imamura Y, Arakawa Y, Ishikawa K. Determination of dosulepin and its metabolite: application of high-performance liquid chromatography with electrochemical detection. J Chromatogr. 1987 Apr 10;415(2):365-71. doi: 10.1016/s0378-4347(00)83228-4. PMID: 3584375. 8: Bukh JD, Jørgensen MB, Dam H, Plenge P. Comparison of the antidepressant effects of venlafaxine and dosulepin in a naturalistic setting. Nord J Psychiatry. 2009;63(4):347-51. doi: 10.1080/08039480902799099. PMID: 19347769. 9: Howell BA, Chauhan A. Binding of imipramine, dosulepin, and opipramol to liposomes for overdose treatment. J Pharm Sci. 2009 Oct;98(10):3718-29. doi: 10.1002/jps.21683. PMID: 19156930. 10: Havránek S, Micek M, Paclt I, Slavícek J, Kittnar O, Dohnalová A, Brizman E, Hála P, Kittzlerová E, Pisvejcová K. QT dispersion estimated from 80 body surface potential map leads and from standard 12-leads ECG in psychiatric patients treated with dosulepin. Prague Med Rep. 2004;105(1):53-63. PMID: 15354946.