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MedKoo Cat#: 576634 | Name: Imidaprilat

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Imidaprilat is an angiotensin-converting enzyme inhibitor that has been shown to inhibit matrix metalloproteinase-2 (MMP-2) activity in human cardiac fibroblasts.

Chemical Structure

Imidaprilat
Imidaprilat
CAS#89371-44-8

Theoretical Analysis

MedKoo Cat#: 576634

Name: Imidaprilat

CAS#: 89371-44-8

Chemical Formula: C18H23N3O6

Exact Mass: 377.1587

Molecular Weight: 377.40

Elemental Analysis: C, 57.29; H, 6.14; N, 11.13; O, 25.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Imidaprilat
IUPAC/Chemical Name
(4S)-3-((2S)-N-((1S)-1-Carboxy-3-phenylpropyl)alanyl)-1-methyl-2-oxo-4-imidazolidinecarboxylic acid
InChi Key
VFAVNRVDTAPBNR-UBHSHLNASA-N
InChi Code
InChI=1S/C18H23N3O6/c1-11(15(22)21-14(17(25)26)10-20(2)18(21)27)19-13(16(23)24)9-8-12-6-4-3-5-7-12/h3-7,11,13-14,19H,8-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,13-,14-/m0/s1
SMILES Code
C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2[C@@H](CN(C)C2=O)C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 377.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Guo XG, Uzui H, Mizuguchi T, Ueda T, Chen JZ, Lee JD. Imidaprilat inhibits matrix metalloproteinase-2 activity in human cardiac fibroblasts induced by interleukin-1beta via NO-dependent pathway. Int J Cardiol. 2008 Jun 6;126(3):414-20. doi: 10.1016/j.ijcard.2007.08.134. Epub 2008 Jan 14. PMID: 18192036. 2. Obata T. Imidaprilat suppresses nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum. Neurosci Res. 2006 Mar;54(3):192-6. doi: 10.1016/j.neures.2005.11.007. Epub 2006 Jan 4. PMID: 16386813. 3. Obata T. Imidaprilat, an angiotensin-converting enzyme inhibitor exerts neuroprotective effect via decreasing dopamine efflux and hydroxyl radical generation induced by bisphenol A and MPP+ in rat striatum. Brain Res. 2006 Feb 3;1071(1):250-3. doi: 10.1016/j.brainres.2005.11.100. Epub 2006 Jan 9. PMID: 16406270.

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