Synonym
Tisopurine; NSC1392; NSC-1392; NSC 1392; DO970; DO-970; DO 970
IUPAC/Chemical Name
1H-Pyrazolo(3,4-d)pyrimidine-4-thiol
InChi Key
PYAOPMWCFSVFOT-UHFFFAOYSA-N
InChi Code
InChI=1S/C5H4N4S/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
SMILES Code
SC1=C2C(NN=C2)=NC=N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
152.18
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Viguier J, d'Alteroche L, Picon L, Karsenti D, Guerin M, Bacq Y, Metman EH. Hépatite aiguë à la tisopurine. Une observation [Acute hepatitis caused by tisopurine. A case]. Gastroenterol Clin Biol. 1997;21(4):342. French. PMID: 9208004.
2: Krulik M, Fkeury J, Audebert AA, Zylberait D, Debray J. Agranulocytose secondaire à un traitement par la tisopurine [Agranulocytosis secondary to a treatment with tisopurine]. Nouv Presse Med. 1980 Sep 20;9(33):2351. French. PMID: 7433031.
3: Pawlotsky Y. Hyperuricémie et goutte: indications thérapeutiques [Hyperuricemia and gout: therapeutic indications]. Rev Prat. 1994 Jan 15;44(2):206-9. French. PMID: 8178077.
4: Marr JJ, Berens RL. Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae. Mol Biochem Parasitol. 1983 Apr;7(4):339-56. doi: 10.1016/0166-6851(83)90016-6. PMID: 6192336.
5: Jawad AS. Alternatives to allopurinol. Ann Rheum Dis. 1987 Jun;46(6):493. doi: 10.1136/ard.46.6.493-a. PMID: 3632073; PMCID: PMC1002174.
6: Klein G, Wottawa A, Rainer F. Untersuchungen zur Wirkung von urikosurisch und urikostatisch wirksamen Substanzen auf den DNA-Stoffwechsel [The effect of uricosuric and uricostatic drugs on DNA metabolism]. Acta Med Austriaca. 1976;3(3):91-7. German. PMID: 1002459.
7: Srivastava R, Mishra A, Pratap R, Bhakuni DS, Srimal RC. Antithrombotic effect of thiopurinol. Thromb Res. 1989 Jun 15;54(6):741-9. doi: 10.1016/0049-3848(89)90138-2. PMID: 2551060.
8: Marr JJ, Berens RL, Nelson DJ, Krenitsky TA, Spector T, LaFon SW, Elion GB. Antileishmanial action of 4-thiopyrazolo (3.4-d) pyrimidine and its ribonucleoside. Biological effects and metabolism. Biochem Pharmacol. 1982 Jan 15;31(2):143-8. doi: 10.1016/0006-2952(82)90203-9. PMID: 7073876.
9: Neal RA, Croft SL, Nelson DJ. Anti-leishmanial effect of allopurinol ribonucleoside and the related compounds, allopurinol, thiopurinol, thiopurinol ribonucleoside, and of formycin B, sinefungin and the lepidine WR6026. Trans R Soc Trop Med Hyg. 1985;79(1):122-8. doi: 10.1016/0035-9203(85)90255-x. PMID: 3992630.
10: MacLeod MC, Mann KL, Thai G, Conti CJ, Reiners JJ Jr. Inhibition by 2,6-dithiopurine and thiopurinol of binding of a benzo(a)pyrene diol epoxide to DNA in mouse epidermis and of the initiation phase of two-stage tumorigenesis. Cancer Res. 1991 Sep 15;51(18):4859-64. PMID: 1909930.
