Synonym
Dixyrazine; UCB3412; UCB-3412; UCB 3412; dixypazin
IUPAC/Chemical Name
10-(2-Methyl-3-(1-hydroxyethoxyethyl-4-piperazinyl)propyl)phenothiazine
InChi Key
AXOHMCJZQBVLIP-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H33N3O2S/c1-19(17-26-13-11-25(12-14-26)15-16-29-20(2)28)18-27-21-7-3-5-9-23(21)30-24-10-6-4-8-22(24)27/h3-10,19-20,28H,11-18H2,1-2H3
SMILES Code
CC(O)OCCN1CCN(CC(C)CN2C3=C(C=CC=C3)SC4=CC=CC=C24)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
427.61
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sridharan K, Sivaramakrishnan G. Drugs for preventing post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: Network meta- analysis of randomized clinical trials and trial sequential analysis. Int J Surg. 2019 Sep;69:1-12. doi: 10.1016/j.ijsu.2019.07.002. Epub 2019 Jul 9. PMID: 31299429.
2: Glaser C, Sitzwohl C, Wallner T, Lerche A, Marhofer P, Schindler I. Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy. Acta Anaesthesiol Scand. 2004 Nov;48(10):1287-91. doi: 10.1111/j.1399-6576.2004.00526.x. PMID: 15504190.
3: Sorbe B, Hallén C. Betamethasone-dixyrazine versus betamethasone- metoclopramide as antiemetic treatment of cisplatin-doxorubicin-induced nausea in ovarian carcinoma patients. Eur J Gynaecol Oncol. 1991;12(1):31-7. PMID: 2050157.
4: Feet PO, Götestam KG. Increased antipanic efficacy in combined treatment with clomipramine and dixyrazine. Acta Psychiatr Scand. 1994 Apr;89(4):230-4. doi: 10.1111/j.1600-0447.1994.tb01506.x. PMID: 7912879.
5: Sorbe B, Hallén C. Betamethasone-dixyrazine versus metoclopramide as antiemetic treatment in cancer chemotherapy. Acta Oncol. 1988;27(4):357-60. doi: 10.3109/02841868809093554. PMID: 3060151.
6: Karlsson E, Larsson LE, Nilsson K. The effects of prophylactic dixyrazine on postoperative vomiting after two different anaesthetic methods for squint surgery in children. Acta Anaesthesiol Scand. 1993 Jan;37(1):45-8. doi: 10.1111/j.1399-6576.1993.tb03596.x. PMID: 8424293.
7: Sorbe B, Hallén C, Skåre NG, Underskog I. Betamethasone-dixyrazine combination versus high-dose metoclopramide as antiemetic treatment in doxorubicin and cisplatin chemotherapy. Radiother Oncol. 1989 Jun;15(2):161-7. doi: 10.1016/0167-8140(89)90130-8. PMID: 2762589.
8: Risberg AM, Risberg J, Elmqvist D, Ingvar DH. Effects of dixyrazine and methaqualone on the sleep pattern in normal man. Eur J Clin Pharmacol. 1975 Apr 4;8(3-4):227-31. doi: 10.1007/BF00567120. PMID: 9296.
9: Kokinsky E, Thornberg E, Nilsson K, Larsson LE. Postoperative nausea and vomiting in children using patient-controlled analgesia: the effect of prophylactic intravenous dixyrazine. Acta Anaesthesiol Scand. 1999 Feb;43(2):191-5. doi: 10.1034/j.1399-6576.1999.430212.x. PMID: 10027027.
10: Oikkonen M, Heine H, Salminen U, Romppanen O, Inberg P. Dixyrazine premedication for cataract surgery. A comparison with diazepam. Acta Anaesthesiol Scand. 1994 Apr;38(3):214-7. doi: 10.1111/j.1399-6576.1994.tb03876.x. PMID: 7912876.
