MedKoo Cat#: 576597 | Name: Olpadronate disodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Olpadronate disodium is an amino-bisphosphonate that may be useful in improving bone mineral density and decreasing the risk of bone fracture.

Chemical Structure

Olpadronate disodium
Olpadronate disodium
CAS#121368-58-9

Theoretical Analysis

MedKoo Cat#: 576597

Name: Olpadronate disodium

CAS#: 121368-58-9

Chemical Formula: C5H13NNa2O9P2

Exact Mass: 338.9861

Molecular Weight: 339.08

Elemental Analysis: C, 17.71; H, 3.86; N, 4.13; Na, 13.56; O, 42.46; P, 18.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
IG 8801 disodium; IG8801 disodium; IG-8801 disodium; Olpadronate disodium; Sodium olpadronate
IUPAC/Chemical Name
Phosphoric acid, (3-(dimethylamino)-1-hydroxypropylidene)bis-, disodium salt
InChi Key
JFGHPLSPUGOSLV-UHFFFAOYSA-L
InChi Code
InChI=1S/C5H15NO7P2.2Na/c1-6(2)4-3-5(7,14(8,9)10)15(11,12)13;;/h7H,3-4H2,1-2H3,(H2,8,9,10)(H2,11,12,13);;/q;2*+1/p-2
SMILES Code
[Na+].[Na+].CN(C)CCC(O)(P(=O)(O)[O-])P(=O)(O)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 339.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Roldán EJ, Pérez-Llore A, Ferretti JL. Olpadronate: a new amino-bisphosphonate for the treatment of medical osteopathies. Expert Opin Investig Drugs. 1998 Sep;7(9):1521-38. doi: 10.1517/13543784.7.9.1521. PMID: 15992050. 2. Sridharan K, Sivaramakrishnan G. Interventions for Improving Bone Mineral Density and Reducing Fracture Risk in Osteogenesis Imperfecta: A Mixed Treatment Comparison Network Meta-analysis of Randomized Controlled Clinical Trials. Curr Clin Pharmacol. 2018;13(3):190-198. doi: 10.2174/1574884713666180829143927. PMID: 30160216. 3. Pelger RC, Hamdy NA, Zwinderman AH, Lycklama à Nijeholt AA, Papapoulos SE. Effects of the bisphosphonate olpadronate in patients with carcinoma of the prostate metastatic to the skeleton. Bone. 1998 Apr;22(4):403-8. doi: 10.1016/s8756-3282(97)00289-5. PMID: 9556142. 4. Cole WG. Olpadronate reduced fractures in children with osteogenesis imperfecta. J Bone Joint Surg Am. 2004 Nov;86(11):2575. doi: 10.2106/00004623-200411000-00051. PMID: 15523042.