Synonym
Diucifon; BRN0956324; BRN-0956324; BRN 0956324
IUPAC/Chemical Name
5-Pyrimidinesulfonamide, N,N'-(sulfonyldi-4,1-phenylene)bis(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-
InChi Key
DVAIYSZTXVOUQZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H20N6O10S3/c1-11-17(19(29)25-21(31)23-11)40(35,36)27-13-3-7-15(8-4-13)39(33,34)16-9-5-14(6-10-16)28-41(37,38)18-12(2)24-22(32)26-20(18)30/h3-10,27-28H,1-2H3,(H2,23,25,29,31)(H2,24,26,30,32)
SMILES Code
O=S(C1=CC=C(NS(C2=C(C)NC(NC2=O)=O)(=O)=O)C=C1)(C3=CC=C(NS(C4=C(C)NC(NC4=O)=O)(=O)=O)C=C3)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
624.61
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gorbunov SM, Anan'ev EV, Zobov VV, Iakubov ShM. Vliianie diutsifona i ego strukturnykh predshestvennikov na vospalitel'nuiu i bolevuiu reaktsii [Effect of diucifon and its structural precursors on inflammatory and pain reactions]. Farmakol Toksikol. 1985 Nov-Dec;48(6):44-7. Russian. PMID: 3878798.
2: Iartsev MN, Komel' GI, Gomes LA. Kontroliruemye randomizirovannye klinicheskie ispytaniia immunomoduliatorov diutsifona i nukleinata natriia u deteĭ s retsidiviruiushchimi gnoĭnymi infektsiiami [Controlled randomized clinical trials of immunomodulators diucifon and sodium nucleinate in children with recurrent suppurative infections]. Pediatriia. 1991;(3):55-9. Russian. PMID: 2047182.
3: Grebeniuk VN, Fedorova EG, Sheklakova MN. Diutsifon v terapii nekotorykh dermatozov [Diucifon in the therapy of dermatoses]. Vestn Dermatol Venerol. 1980 Feb;(2):41-3. Russian. PMID: 6986724.
4: Murav'ev IuV. Metodika lecheniia preparatami salazopiridazin i diutsifon [Method of treatment with salazopyridazine and diucifon]. Revmatologiia (Mosk). 1990 Apr-Jun;(2):72-3. Russian. PMID: 1977195.
5: Tkachuk MG, Stradina MS. [Morphological changes in the thymus during the physical loads applied simultaneously with the administration of diucifon and in the rehabilitation period]. Morfologiia. 2007;132(5):63-8. Russian. PMID: 18198675.
6: Leskov VP, Pisarev VM, Arshinova SS. Issledovanie deĭstviia singennykh kletok selezenki mysheĭ, obrabotannykh diutsifonom, na velichinu immunnogo otveta [Action of diucifon-treated syngeneic splenic cells of mice on the magnitude of the immune response]. Biull Eksp Biol Med. 1984 Oct;98(10):474-6. Russian. PMID: 6388660.
7: Leskov VP, Prozorovskiĭ NS, Gushchin IS, Rozinov MN. Issledovanie nekotorykh svoĭstv faktora rosta T-kletok, poluchennogo iz limfotsitov cheloveka, stimulirovannykh diutsifonom [Properties of T-cell growth factor obtained from diucifon-stimulated human lymphocytes]. Biull Eksp Biol Med. 1985 Dec;100(12):738-40. Russian. PMID: 3878162.
8: Prozorovskiĭ NS, Leskov VP, Gushchin IS. Reguliatornoe deĭstvie mononuklearnykh kletok cheloveka, obrabotannykh diutsifonom, mozhet oposredovat'sia membranoassotsiirovannoĭ formoĭ interleĭkina -2 [Regulatory effects of human mononuclear cells treated with diucifon may be dependent on membrane-associated form of interleukin-2]. Biull Eksp Biol Med. 1991 Aug;112(8):174-6. Russian. PMID: 1786382.
9: Konstantinova NP, Belokrinitskiĭ DV, Kochetova SV, Shelepin AA. Kliniko- immunologicheskoe obosnovanie primeneniia diutsifona u bol'nykh khronicheskim tonzillitom [Clinico-immunologic substantiation of the use of diucifon in patients with chronic tonsillitis]. Vestn Otorinolaringol. 1985 Nov- Dec;(6):49-52. Russian. PMID: 3879034.
10: Totibadze NV, Suleĭmanova NS, Van'ko LV, Fisenko AP, Sukhikh GT. Vliianie diutsifona na estestvennuiu tsitotoksicheskuiu aktivnost' kletok selezenki starykh mysheĭ [Effect of diucifon on the natural cytotoxic activity of splenic cells in old rats]. Biull Eksp Biol Med. 1988 Aug;106(8):189-91. Russian. PMID: 3261997.
