QD-394 is an inducer of reactive oxygen species (ROS) production. It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 µM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 µM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.
MedKoo Cat#: 464560
Name: QD-394
CAS#: 2132411-21-1
Chemical Formula: C19H19N5O2
Exact Mass: 349.1539
Molecular Weight: 349.39
Elemental Analysis: C, 65.32; H, 5.48; N, 20.04; O, 9.16
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 1.0 | 2.86 | |
| DMSO | 5.0 | 14.31 | |
| DMSO:PBS (pH 7.2) (1:20) | 0.0 | 0.11 | |
| Ethanol | 1.0 | 2.86 |
The following data is based on the product molecular weight 349.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
