AZ3146 is a novel and potent Mps1 inhibitor, which was used to probe the role of Mps1's catalytic activity during mitosis. AZ3146 also inhibits FAK, JNK1, JNK2, KSP and Kit. In in vitro kinase assays, AZ3146 inhibited human Mps1Cat with an IC50 (50% inhibitory concentration) of ~35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells.
MedKoo Cat#: 406239
Name: AZ3146
CAS#: 1124329-14-1
Chemical Formula: C24H32N6O3
Exact Mass: 452.2536
Molecular Weight: 452.55
Elemental Analysis: C, 63.70; H, 7.13; N, 18.57; O, 10.61
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.9 | 77.12 | |
| DMF | 5.0 | 11.05 | |
| DMF:PBS (pH 7.2) (1:1) | 0.5 | 1.10 | |
| Ethanol | 42.3 | 93.49 |
The following data is based on the product molecular weight 452.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
