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MedKoo Cat#: 576552 | Name: ICR-191 dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICR-191 dihydrochloride is a mutagen that induces frameshifts in DNA via intercalation.

Chemical Structure

ICR-191 dihydrochloride
ICR-191 dihydrochloride
CAS#17070-45-0

Theoretical Analysis

MedKoo Cat#: 576552

Name: ICR-191 dihydrochloride

CAS#: 17070-45-0

Chemical Formula: C19H23Cl4N3O

Exact Mass: 449.0595

Molecular Weight: 451.21

Elemental Analysis: C, 50.58; H, 5.14; Cl, 31.43; N, 9.31; O, 3.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
ICR-191 dihydrochloride; ICR191 dihydrochloride; ICR 191 dihydrochloride; ICR-191 2HCl
IUPAC/Chemical Name
6-Chloro-9-((3-((2-chloroethyl)amino)propyl)amino)-2-methoxyacridine dihydrochloride
InChi Key
LMEMIKWTNPWYMI-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21Cl2N3O.2ClH/c1-25-14-4-6-17-16(12-14)19(23-9-2-8-22-10-7-20)15-5-3-13(21)11-18(15)24-17;;/h3-6,11-12,22H,2,7-10H2,1H3,(H,23,24);2*1H
SMILES Code
[Cl-].[Cl-].COc1ccc2nc3cc(Cl)ccc3c([NH2+]CCC[NH2+]CCCl)c2c1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 451.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1.Gołuński G, Woziwodzka A, Iermak I, Rychłowski M, Piosik J. Modulation of acridine mutagen ICR191 intercalation to DNA by methylxanthines--analysis with mathematical models. Bioorg Med Chem. 2013 Jun 1;21(11):3280-9. doi: 10.1016/j.bmc.2013.03.043. Epub 2013 Apr 3. PMID: 23601817. 2. Chen WD, Eshleman JR, Aminoshariae MR, Ma AH, Veloso N, Markowitz SD, Sedwick WD, Veigl ML. Cytotoxicity and mutagenicity of frameshift-inducing agent ICR191 in mismatch repair-deficient colon cancer cells. J Natl Cancer Inst. 2000 Mar 15;92(6):480-5. doi: 10.1093/jnci/92.6.480. PMID: 10716966. 3. Ghaedi K, Fujiki Y. Isolation and characterization of novel phenotype CHO cell mutants defective in peroxisome assembly, using ICR191 as a potent mutagenic agent. Cell Biochem Funct. 2008 Aug;26(6):684-91. doi: 10.1002/cbf.1493. PMID: 18543353. 4. Zientek-Targosz H, Kunnev D, Hawthorn L, Venkov M, Matsui S, Cheney RT, Ionov Y. Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: a model for identifying candidate breast-tumor suppressors. Mol Cancer. 2008 Jun 5;7:51. doi: 10.1186/1476-4598-7-51. PMID: 18534021; PMCID: PMC2430587.