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MedKoo Cat#: 464536 | Name: SW-101

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SW-101 is a potent and selective HDAC6 inhibitor that possesses excellent HDAC6 potency and selectivity, together with markedly improved metabolic stability and druglike properties compared to SW-100.

Chemical Structure

SW-101
SW-101
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464536

Name: SW-101

CAS#: unknown

Chemical Formula: C18H19N3O3

Exact Mass: 325.1426

Molecular Weight: 325.37

Elemental Analysis: C, 66.45; H, 5.89; N, 12.91; O, 14.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SW-101; SW101; SW 101;
IUPAC/Chemical Name
1-(4-(hydroxycarbamoyl)benzyl)-1,2,3,4-tetrahydroquinoline-6-carboxamide
InChi Key
ZRFMDXMQBRKKOA-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H19N3O3/c19-17(22)15-7-8-16-14(10-15)2-1-9-21(16)11-12-3-5-13(6-4-12)18(23)20-24/h3-8,10,24H,1-2,9,11H2,(H2,19,22)(H,20,23)
SMILES Code
ONC(C1=CC=C(C=C1)CN(CCC2)C3=C2C=C(C(N)=O)C=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 325.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shen S, Picci C, Ustinova K, Benoy V, Kutil Z, Zhang G, Tavares MT, Pavlíček J, Zimprich CA, Robers MB, Van Den Bosch L, Bařinka C, Langley B, Kozikowski AP. Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model. J Med Chem. 2021 Apr 8. doi: 10.1021/acs.jmedchem.0c02210. Epub ahead of print. PMID: 33830764.