DNF-3 | CAS#unknown | Antitubercular agent

MedKoo Cat#: 464529 | Name: DNF-3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DNF-3 is an antitubercular agent. DNF-3 showed strong activity against Mtb strains, with an MIC50 of 0.19 μg/mL, both against H37Rv and XDR-TB, respectively. DNF-3 was then selected for further study todetermine if it would be suitable as a potential anti-TB drug.

Chemical Structure

DNF-3

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464529

Name: DNF-3

CAS#: unknown

Chemical Formula: C28H25NO6

Exact Mass: 471.1682

Molecular Weight: 471.51

Elemental Analysis: C, 71.33; H, 5.34; N, 2.97; O, 20.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DNF-3; DNF3; DNF 3;

IUPAC/Chemical Name

methyl 5-(2-(diethylamino)ethoxy)-7,12-dioxo-7,12-dihydrodinaphtho[1,2-b:2',3'-d]furan-6-carboxylate

InChi Key

OHYFDYUPUPHUDP-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H25NO6/c1-4-29(5-2)14-15-34-25-18-12-8-9-13-19(18)26-20(22(25)28(32)33-3)21-23(30)16-10-6-7-11-17(16)24(31)27(21)35-26/h6-13H,4-5,14-15H2,1-3H3

SMILES Code

O=C(C1=C2C(OC(C(C3=C4C=CC=C3)=O)=C2C4=O)=C5C=CC=CC5=C1OCCN(CC)CC)OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 471.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Islam MI, Han CM, Seo H, Kim S, Mahmud HA, Nam KW, Lee BE, Sadu VS, Lee KI, Song HY. In vitro activity of DNF-3 against drug-resistant Mycobacterium tuberculosis. Int J Antimicrob Agents. 2019 Jul;54(1):69-74. doi: 10.1016/j.ijantimicag.2019.02.013. Epub 2019 Feb 23. PMID: 30807817.