CYR715 is a novel carboxylic acid-containing soluble guanylate cyclase stimulator. CYR715 addressed potential idiosyncratic drug toxicity (IDT) liabilities associated with the formation of reactive, migrating acyl glucuronides (AG) found in related carboxylic acid-containing analogs and demonstrated high oral bioavailability in rat and dose-dependent hemodynamic pharmacology in normotensive Sprague–Dawley rats.
MedKoo Cat#: 464526
Name: CYR715
CAS#: unknown
Chemical Formula: C24H22F2N6O3
Exact Mass: 480.1721
Molecular Weight: 480.48
Elemental Analysis: C, 60.00; H, 4.62; F, 7.91; N, 17.49; O, 9.99
The following data is based on the product molecular weight 480.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
