BI-1046 has been identified as a potent and selective GPR142 agonist which increases Gq-coupled signalling in cells of recombinant and endogenous (mouse insulinoma cell line Min-6) receptor expression. The GPR142 agonistic activity of BI-1046 has been demonstrated to potentiate glucose-stimulated insulin secretion from mouse islets, a physiological response that translates into improved glucose tolerance in mice when investigated in an acute oral glucose tolerance test.
MedKoo Cat#: 464520
Name: BI-1046
CAS#: unknown
Chemical Formula: C20H15F3N6O
Exact Mass: 412.1259
Molecular Weight: 412.38
Elemental Analysis: C, 58.25; H, 3.67; F, 13.82; N, 20.38; O, 3.88
The following data is based on the product molecular weight 412.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
