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MedKoo Cat#: 464497 | Name: Flubrotizolam
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flubrotizolam is an analytical reference standard categorized as a thienodiazepine. This product is intended for research and forensic applications.

Chemical Structure

Flubrotizolam
Flubrotizolam
CAS#57801-95-3

Theoretical Analysis

MedKoo Cat#: 464497

Name: Flubrotizolam

CAS#: 57801-95-3

Chemical Formula: C15H10BrFN4S

Exact Mass: 375.9794

Molecular Weight: 377.24

Elemental Analysis: C, 47.76; H, 2.67; Br, 21.18; F, 5.04; N, 14.85; S, 8.50

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 1,050.00 2 Weeks
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Related CAS #
No Data
Synonym
Flubrotizolam;
IUPAC/Chemical Name
2-bromo-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
InChi Key
VOZDBDBHBXLWCG-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10BrFN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3
SMILES Code
CC1=NN=C2CN=C(C3=C(N21)SC(Br)=C3)C4=CC=CC=C4F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 5.0 13.00
DMSO 5.0 13.00
DMSO:PBS (pH 7.2) (1:1) 0.5 1.30
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 377.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Toxicol Appl Pharmacol. 2023 Apr 15;465:116459. doi: 10.1016/j.taap.2023.116459. Epub 2023 Mar 11. PMID: 36907383. 9: Vekic N, Armstrong-Price D, Woodall K. Flualprazolam and flubromazolam: Blood concentrations and prevalence of two novel psychoactive substances in forensic case work in Ontario, Canada. J Anal Toxicol. 2023 Nov 1;47(8):762-769. doi: 10.1093/jat/bkad058. PMID: 37930844. 10: Pope JD, Weng Choy K, Drummer OH, Schneider HG. Novel Benzodiazepines (Clonazolam and Flubromazolam) Identified in Candy-Like Pills. J Appl Lab Med. 2018 Jul 1;3(1):48-55. doi: 10.1373/jalm.2017.025387. PMID: 33626826. 11: Noble C, Mardal M, Bjerre Holm N, Stybe Johansen S, Linnet K. In vitro studies on flubromazolam metabolism and detection of its metabolites in authentic forensic samples. Drug Test Anal. 2017 Aug;9(8):1182-1191. doi: 10.1002/dta.2146. Epub 2017 Feb 10. PMID: 27935260. 12: Wohlfarth A, Vikingsson S, Roman M, Andersson M, Kugelberg FC, Green H, Kronstrand R. Looking at flubromazolam metabolism from four different angles: Metabolite profiling in human liver microsomes, human hepatocytes, mice and authentic human urine samples with liquid chromatography high-resolution mass spectrometry. Forensic Sci Int. 2017 May;274:55-63. doi: 10.1016/j.forsciint.2016.10.021. Epub 2016 Nov 5. PMID: 27863836. 13: Andersson M, Kjellgren A. The slippery slope of flubromazolam: Experiences of a novel psychoactive benzodiazepine as discussed on a Swedish online forum. Nordisk Alkohol Nark. 2017 Jun;34(3):217-229. doi: 10.1177/1455072517706304. Epub 2017 May 16. PMID: 32934486; PMCID: PMC7450873. 14: Pettersson Bergstrand M, Meyer MR, Beck O, Helander A. Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography-high resolution mass spectrometry. Drug Test Anal. 2018 Mar;10(3):496-506. doi: 10.1002/dta.2243. Epub 2017 Aug 29. PMID: 28677876. 15: Brunetti P, Giorgetti R, Tagliabracci A, Huestis MA, Busardò FP. Designer Benzodiazepines: A Review of Toxicology and Public Health Risks. Pharmaceuticals (Basel). 2021 Jun 11;14(6):560. doi: 10.3390/ph14060560. PMID: 34208284; PMCID: PMC8230725. 16: El Balkhi S, Monchaud C, Herault F, Géniaux H, Saint-Marcoux F. Designer benzodiazepines' pharmacological effects and potencies: How to find the information. J Psychopharmacol. 2020 Sep;34(9):1021-1029. doi: 10.1177/0269881119901096. Epub 2020 Jan 23. PMID: 31971477. 17: Edinoff AN, Nix CA, Odisho AS, Babin CP, Derouen AG, Lutfallah SC, Cornett EM, Murnane KS, Kaye AM, Kaye AD. Novel Designer Benzodiazepines: Comprehensive Review of Evolving Clinical and Adverse Effects. Neurol Int. 2022 Aug 22;14(3):648-663. doi: 10.3390/neurolint14030053. PMID: 35997362; PMCID: PMC9397074. 18: Bollinger K, Weimer B, Heller D, Bynum N, Grabenauer M, Pressley D, Smiley- McDonald H. Benzodiazepines reported in NFLIS-Drug, 2015 to 2018. Forensic Sci Int Synerg. 2021 Feb 9;3:100138. doi: 10.1016/j.fsisyn.2021.100138. PMID: 33665593; PMCID: PMC7905184. 19: Pettersson Bergstrand M, Richter LHJ, Maurer HH, Wagmann L, Meyer MR. In vitro glucuronidation of designer benzodiazepines by human UDP- glucuronyltransferases. Drug Test Anal. 2019 Jan;11(1):45-50. doi: 10.1002/dta.2463. Epub 2018 Aug 9. PMID: 29996009. 20: Heide G, Høiseth G, Middelkoop G, Øiestad ÅML. Blood Concentrations of Designer Benzodiazepines: Relation to Impairment and Findings in Forensic Cases. J Anal Toxicol. 2020 Dec 12;44(8):905-914. doi: 10.1093/jat/bkaa043. PMID: 32369173; PMCID: PMC7733327.