MedKoo Cat#: 576515 | Name: ICI-162846

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-162846 is a H2-antagonist that has been shown to inhibit both basal and pentagastrin stimulated acid secretion by 50% or more in a chronic duodenal ulcer model.

Chemical Structure

ICI-162846
ICI-162846
CAS#84545-30-2

Theoretical Analysis

MedKoo Cat#: 576515

Name: ICI-162846

CAS#: 84545-30-2

Chemical Formula: C11H17F3N6O

Exact Mass: 306.1416

Molecular Weight: 306.29

Elemental Analysis: C, 43.14; H, 5.59; F, 18.61; N, 27.44; O, 5.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ICI 162846; ICI162846; ICI-162846
IUPAC/Chemical Name
1H-Pyrazole-1-pentanamide, 3-((imino((2,2,2-trifluoroethyl)amino)methyl)amino)-
InChi Key
ALCSGJCIESECFD-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H17F3N6O/c12-11(13,14)7-17-10(16)18-9-4-6-20(19-9)5-2-1-3-8(15)21/h4,6H,1-3,5,7H2,(H2,15,21)(H3,16,17,18,19)
SMILES Code
NC(=O)CCCCn1ccc(NC(=N)NCC(F)(F)F)n1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 306.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Gompertz RH, Man WK, Li SK, Spencer J, Baron JH, Michalowski AS. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions. 1991 May;33(1-2):161-3. doi: 10.1007/BF01993155. PMID: 1716826. 2. Streett CS, Robertson JL, Crissman JW. Morphologic stomach findings in rats and mice treated with the H2 receptor antagonists, ICI 125,211 and ICI 162,846. Toxicol Pathol. 1988;16(2):299-304. doi: 10.1177/019262338801600223. PMID: 2903545. 3. Wilson JA, Johnston DA, Penston J, Wormsley KG. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21(6):685-9. doi: 10.1111/j.1365-2125.1986.tb05234.x. PMID: 2874823; PMCID: PMC1400977.