UCSF924 is a selective, high-affinity dopamine D4 receptor (DRD4) partial agonist (Ki = 3 nM for human D4) with a 7.4-fold bias toward arrestin recruitment over Gαi (Gαi/0; Gi/G0) signaling activation with respect to quinpirole. UCSF924 exhibits no detectable affinity for D2, D3 or the F261V/L328F D4 mutant and no agonist activity toward a panel of 320 nonolfactory GPCRs even at a high concentration of 1 μM. The UCSF924 structure analog UCSF924NC is the recommended negative control compound with a 1/2500-fold reduced D4 affinity.
MedKoo Cat#: 464459
Name: UCSF924
CAS#: 1434515-70-4
Chemical Formula: C20H22N2O2
Exact Mass: 322.1681
Molecular Weight: 322.41
Elemental Analysis: C, 74.51; H, 6.88; N, 8.69; O, 9.92
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.0 | 124.00 |
The following data is based on the product molecular weight 322.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
