MedKoo Cat#: 413794 | Name: Dioxidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dioxidine is an antibacterial drug for the treatment of suppurative infections.

Chemical Structure

Dioxidine
Dioxidine
CAS#17311-31-8

Theoretical Analysis

MedKoo Cat#: 413794

Name: Dioxidine

CAS#: 17311-31-8

Chemical Formula: C10H10N2O4

Exact Mass: 222.0641

Molecular Weight: 222.20

Elemental Analysis: C, 54.05; H, 4.54; N, 12.61; O, 28.80

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Synonym
Dioxidine
IUPAC/Chemical Name
2,3-Bis(hydroxymethyl)quinoxaline-1,4-dioxide
InChi Key
DOIGHQCAQBRSKI-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H10N2O4/c13-5-9-10(6-14)12(16)8-4-2-1-3-7(8)11(9)15/h1-4,13-14H,5-6H2
SMILES Code
[O-][N+]1=C2C=CC=CC2=[N+]([O-])C(CO)=C1CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Dioxidine is an antibacterial drug for the treatment of suppurative infections.
In vitro activity:
Significant individual differences were found in the levels of methylation in both native peripheral blood lymphocyte cells and in cells treated with dioxidine in both concentrations. Mean group indicators of methylation did not differ before culturing and after 25 h in culture (45.28 and 44.80%, respectively). The mean group rate of methylation increased to 46.14% (p<0.001) after dioxidine treatment in a concentration of 0.01 mg/ml. Dioxidine in 0.1 mg/ml reduced the level of methylation (mean group rate 42.31%; p<0.001). Reference: Bull Exp Biol Med. 2013 Jun;155(2):224-7. https://pubmed.ncbi.nlm.nih.gov/24130996/
In vivo activity:
The cytogenetic activity and mutagen-modifying effect of the plant growth regulator 2,6-dimethylpyridine-N-oxide (Ivin) were studied by the method of accounting for chromosomal aberrations in the bone marrow cells of CD-1 mice (males) with a single joint exposure with Dioxidine. Reference: Georgian Med News. 2021 May;(314):139-145. https://pubmed.ncbi.nlm.nih.gov/34248044/

Preparing Stock Solutions

The following data is based on the product molecular weight 222.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Smirnikhina SA, Voronina ES, Lavrov AV, Bochkov NP. Dioxidine-induced changes in genome-wide DNA methylation in a culture of peripheral blood lymphocytes. Bull Exp Biol Med. 2013 Jun;155(2):224-7. doi: 10.1007/s10517-013-2119-z. PMID: 24130996. 2. Sidneva ES, Katosova LD, Platonova VI, Beketova NA, Kodentsova VM, Chebotarev AN, Durnev AD, Bochkov NP. Effects of vitamin supply on spontaneous and chemically induced mutagenesis in human cells. Bull Exp Biol Med. 2005 Feb;139(2):230-4. English, Russian. doi: 10.1007/s10517-005-0256-8. PMID: 16027815. 3. Vasetska O, Zubko O, Prodanchuk M, Kravchuk O, Zhminko P. EFFECT OF 2,6-DIMETHYLPYRIDINE-N-OXIDE ON THE SEVERITY OF CYTOGENETIC EFFECTS INDUCED BY DIOXIDINE IN BONE MARROW CELLS OF MICE. Georgian Med News. 2021 May;(314):139-145. PMID: 34248044. 4. Zhanataev AK, Presnova GA, Chistyakov AN, Durnev AD. Effect of Betula bark extract on spontaneous and induced mutagenesis in mice. Bull Exp Biol Med. 2004 Nov;138(5):475-8. doi: 10.1007/s10517-005-0074-z. PMID: 15723130.
In vitro protocol:
1. Smirnikhina SA, Voronina ES, Lavrov AV, Bochkov NP. Dioxidine-induced changes in genome-wide DNA methylation in a culture of peripheral blood lymphocytes. Bull Exp Biol Med. 2013 Jun;155(2):224-7. doi: 10.1007/s10517-013-2119-z. PMID: 24130996. 2. Sidneva ES, Katosova LD, Platonova VI, Beketova NA, Kodentsova VM, Chebotarev AN, Durnev AD, Bochkov NP. Effects of vitamin supply on spontaneous and chemically induced mutagenesis in human cells. Bull Exp Biol Med. 2005 Feb;139(2):230-4. English, Russian. doi: 10.1007/s10517-005-0256-8. PMID: 16027815.
In vivo protocol:
1. Vasetska O, Zubko O, Prodanchuk M, Kravchuk O, Zhminko P. EFFECT OF 2,6-DIMETHYLPYRIDINE-N-OXIDE ON THE SEVERITY OF CYTOGENETIC EFFECTS INDUCED BY DIOXIDINE IN BONE MARROW CELLS OF MICE. Georgian Med News. 2021 May;(314):139-145. PMID: 34248044. 2. Zhanataev AK, Presnova GA, Chistyakov AN, Durnev AD. Effect of Betula bark extract on spontaneous and induced mutagenesis in mice. Bull Exp Biol Med. 2004 Nov;138(5):475-8. doi: 10.1007/s10517-005-0074-z. PMID: 15723130.
1: Detysheva EV, Fursova NK, Korovkin SA. [Antimicrobial activity of dioxidine and a dioxidin-containing preparation «Nosolin-Ultra, nasal drops».]. Klin Lab Diagn. 2020;65(4):244-250. Russian. doi: 10.18821/0869-2084-2020-65-4-244-250. PMID: 32227731. 2: Lozinsky VI, Shchekoltsova AO, Sinitskaya ES, Vernaya OI, Nuzhdina AV, Bakeeva IV, Ezernitskaya MG, Semenov AM, Shabatina TI, Melnikov MY. Influence of succinylation of a wide-pore albumin cryogels on their properties, structure, biodegradability, and release dynamics of dioxidine loaded in such spongy carriers. Int J Biol Macromol. 2020 Oct 1;160:583-592. doi: 10.1016/j.ijbiomac.2020.05.251. Epub 2020 May 30. PMID: 32479937. 3: Smirnikhina SA, Voronina ES, Lavrov AV, Bochkov NP. Dioxidine-induced changes in genome-wide DNA methylation in a culture of peripheral blood lymphocytes. Bull Exp Biol Med. 2013 Jun;155(2):224-7. doi: 10.1007/s10517-013-2119-z. PMID: 24130996. 4: Bol'shakov LV. Antibakterial'naia aktivnost' dioksidina v usloviiakh aéroi anaérobioza [Antibacterial activity of dioxidine under aero- and anaerobic conditions]. Antibiot Med Biotekhnol. 1986 Oct;31(10):760-4. Russian. PMID: 3789685. 5: Ovchinnikov AY, Yeghian SS. [Efficacy of Dioxidine antimicrobial preparation for the treatment of inflammatory diseases of the external and middle ear]. Vestn Otorinolaringol. 2016;81(2):61-66. Russian. doi: 10.17116/otorino201681261-66. PMID: 27213660. 6: Shashkina LF, Ivanova VM, Lavrik OI, Proĭnova VA, Nechushkina LV. Izuchenie kantserogennoĭ aktivnosti dioksidina [Carcinogenic activity of dioxidine]. Farmakol Toksikol. 1985 Jan-Feb;48(1):77-80. Russian. PMID: 3979542. 7: Polukhina LM, Padeĭskaia EN, Granik EM, Pershin GN. Izuchenie vyvedeniia dioksidina i khinoksidina s mochoĭ v opytakh na myshakh [Urinary excretion of dioxidine and quinoxidine in experiments on mice]. Farmakol Toksikol. 1977 Jul- Aug;40(4):478-81. Russian. PMID: 902753. 8: Bogdanets LI, Smirnova ES, Vasil'ev IM. [Efficiveness of Dioxidine in the treatment of trophic ulcers of venous etiology]. Khirurgiia (Mosk). 2014;(9):64-7. Russian. PMID: 25327749. 9: Bakuleva NP, Anuchina NM, Zelivjanskaja MV, Kostava VT, Kondratenko ZhE, Lyutova IG, Popov DA, Tereshchenkova IA. [Preclinical tests of dioxidine as a decontaminating agent for cardiac valve bioimplants]. Med Tekh. 2015 May- Jun;(3):28-31. Russian. PMID: 26442330. 10: Sycheva LP, Kovalenko MA, Sheremeteva SM, Durnev AD, Zhurkov VS. Study of mutagenic activity of dioxidine by the polyorgan micronuclear method. Bull Exp Biol Med. 2004 Aug;138(2):165-7. doi: 10.1023/b:bebm.0000048377.39895.99. PMID: 15662461.