MedKoo Cat#: 576473 | Name: ICI-106270

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-106270 is a potent anti-hypertensive agent with similar mechanism of action to clonidine.

Chemical Structure

ICI-106270
ICI-106270
CAS#67249-51-8

Theoretical Analysis

MedKoo Cat#: 576473

Name: ICI-106270

CAS#: 67249-51-8

Chemical Formula: C12H12ClFN2

Exact Mass: 238.0673

Molecular Weight: 238.69

Elemental Analysis: C, 60.38; H, 5.07; Cl, 14.85; F, 7.96; N, 11.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ICI 106270; ICI106270; ICI-106270
IUPAC/Chemical Name
3H-Pyrrolo(1,2-a)imidazole, 6-(2-chloro-6-fluorophenyl)-2,5,6,7-tetrahydro-
InChi Key
VDDKWLCHDOJXJM-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H12ClFN2/c13-9-2-1-3-10(14)12(9)8-6-11-15-4-5-16(11)7-8/h1-3,8H,4-7H2
SMILES Code
Fc1cccc(Cl)c1C2CN3CCN=C3C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 238.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Ruffolo RR Jr, Yaden EL, Timmermans PB, van Zwieten PA, Hynes MD. Characterization of the alpha adrenoceptor-mediated effects and antihypertensive activity of ICI 106270: comparison with clonidine. J Pharmacol Exp Ther. 1984 Apr;229(1):58-66. PMID: 6323690. 2. Clough DP, Hatton R, Pettinger SJ. A new centrally acting antihypertensive (ICI 106270) which separates antihypertensive effects from sedation. Arzneimittelforschung. 1981;31(10):1698-703. PMID: 7198445.