MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 413789 | Name: Dioxadet

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dioxadet is a biochemical with antitumor activity

Chemical Structure

Dioxadet
Dioxadet
CAS# 67026-12-4

Theoretical Analysis

MedKoo Cat#: 413789

Name: Dioxadet

CAS#: 67026-12-4

Chemical Formula: C14H22N6O3

Exact Mass: 322.1753

Molecular Weight: 322.37

Elemental Analysis: C, 52.16; H, 6.88; N, 26.07; O, 14.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Dioxadet; NSC275656; NSC-275656; NSC 275656
IUPAC/Chemical Name
(5-((4,6-di(aziridin-1-yl)-1,3,5-triazin-2-yl)amino)-2,2-dimethyl-1,3-dioxan-5-yl)methanol
InChi Key
QKBGEGKCGLXDSG-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H22N6O3/c1-13(2)22-8-14(7-21,9-23-13)18-10-15-11(19-3-4-19)17-12(16-10)20-5-6-20/h21H,3-9H2,1-2H3,(H,15,16,17,18)
SMILES Code
CC1(OCC(CO1)(Nc2nc(N3CC3)nc(N4CC4)n2)CO)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 322.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhikhoreva AA, Belashov AV, Bespalov VG, Semenov AL, Semenova IV, Tochilnikov GV, Zhilinskaya NT, Vasyutinskii OS. Morphological changes in the ovarian carcinoma cells of Wistar rats induced by chemotherapy with cisplatin and dioxadet. Biomed Opt Express. 2018 Oct 29;9(11):5817-5827. doi: 10.1364/BOE.9.005817. PMID: 30460164; PMCID: PMC6238906. 2: Bespalov VG, Kireeva GS, Belyaeva OA, Senchik KY, Stukov AN, Maydin MA, Semenov AL, Gafton GI, Guseynov KD, Belyaev AM. Experimental study of antitumour activity and effects on leukocyte count of intraperitoneal administration and hyperthermic intraperitoneal chemoperfusion (HIPEC) with dioxadet in a rat model of ovarian cancer. J Chemother. 2016 Jun;28(3):203-9. doi: 10.1179/1973947815Y.0000000040. PMID: 26027427. 3: Bespalov VG, Kireeva GS, Belyaeva OA, Kalinin OE, Senchik KY, Stukov AN, Gafton GI, Guseynov KD, Belyaev AM. Both heat and new chemotherapeutic drug dioxadet in hyperthermic intraperitoneal chemoperfusion improved survival in rat ovarian cancer model. J Surg Oncol. 2016 Mar;113(4):438-42. doi: 10.1002/jso.24140. Epub 2015 Dec 29. PMID: 26710749. 4: Bespalov VG, Beliaeva OA, Kireeva GS, Senchik KIu, Stukov AN, Aristova VA, Vyshinskaia EA, Kon'kov SA, Krylova IA, Semënov AL, Maĭdin MA, Aleksandrov VA, Beliaev AM. [Antitumor effect of dioxadet in intraperitoneal chemoperfusion treatment for advanced ovarian cancer in experimental setting]. Vopr Onkol. 2014;60(2):72-9. Russian. PMID: 24919266. 5: Latipova DKh, Gershanovich ML, Stukov AN, Semiglazova TIu, Filatova LV, Tarasenkova AA, Vershinina SF, Kon'kov SA, Krylova IM, Bespalov VG, Panchenko AV, Murazov IaG. [Synergism of antitumor activity of gemcitabine and dioxadet in mice with ascitic Ehrlich's tumor]. Vopr Onkol. 2011;57(6):767-70. Russian. PMID: 22416395. 6: Bespalov VG, Kireeva GS, Belyaeva OA, Senchik KY, Stukov AN, Gafton GI, Soloviev LA, Vasilchenko MV, Guseinov KD, Alexeev VV, Belyaev AM. [Intraoperative intraperitoneal chemoperfusion treatment with cisplatin and dioxadet on a model of peritoneal carcinomatosis in ovarian cancer: safety and efficacy evaluation]. Vopr Onkol. 2015;61(4):647-52. Russian. PMID: 26571838. 7: Bespalov VG, Alvovsky IK, Tochilnikov GV, Stukov AN, Vyshinskaya EA, Semenov AL, Vasilyeva IN, Belyaeva OA, Kireeva GS, Senchik KY, Zhilinskaya NT, Von JD, Krasilnikova LA, Alexandrov VA, Khromov-Borisov NN, Baranenko DA, Belyaev AM. Comparative efficacy evaluation of catheter intraperitoneal chemotherapy, normothermic and hyperthermic chemoperfusion in a rat model of ascitic ovarian cancer. Int J Hyperthermia. 2018 Aug;34(5):545-550. doi: 10.1080/02656736.2017.1375161. Epub 2017 Sep 18. PMID: 28893108. 8: Bespalov VG, Vyshinskaya EA, Vasilieva IN, Maidin MA, Semenov AL, Stukov AN, Kireeva GS, Belyaeva OA, Kopteva OS, Krasilnikova LA, Alexandrov VA, Belyaev AM. [Intraperitoneal chemotherapy--a method of improving treatment effectiveness in ovarian cancer]. Vopr Onkol. 2015;61(4):634-41. Russian. PMID: 26571836. 9: Bespalov VG, Beliaeva OA, Panchenko AV, Stukov AN, Gershanovich ML, Murazov IaG, Kon'kov SA, Kil'maeva NE, Krylova IM, Mironiuk TA, Latipova DKh. [Antitumor activity of dioxadet compared with cisplatin on ascitic ovarian tumor in rats]. Vopr Onkol. 2011;57(6):771-4. Russian. PMID: 22416396. 10: Stukov AN, Korsakov MV, Khrapova TN, Kil'maeva NE, Kraĭz BO. Vliianie dioksadéta na opukholi, perevitye v golovnoĭ mozg [Effect of dioxadet on tumors transplanted to the brain]. Vopr Onkol. 1986;32(10):64-7. Russian. PMID: 3776129.