Synonym
Dioxadrol; Oxadrolum
IUPAC/Chemical Name
1,3-Dioxolane, 2,2-diphenyl-4-(2'-piperidyl)-
InChi Key
HGKAMARNFGKMLC-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H23NO2/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18/h1-6,9-12,18-19,21H,7-8,13-15H2
SMILES Code
C1(C2NCCCC2)OC(C3=CC=CC=C3)(C4=CC=CC=C4)OC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
309.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Banerjee A, Schepmann D, Wünsch B. Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues. Bioorg Med Chem. 2010 Jun 1;18(11):4095-102. doi: 10.1016/j.bmc.2010.04.002. Epub 2010 Apr 4. PMID: 20451396.
2: Slifer BL, Balster RL. Phencyclidine-like discriminative stimulus properties of the stereoisomers of dioxadrol. Subst Alcohol Actions Misuse. 1984-1985;5(6):273-80. PMID: 6545061.
3: Jacobson AE, Harrison EA Jr, Mattson MV, Rafferty MF, Rice KC, Woods JH, Winger G, Solomon RE, Lessor RA, Silverton JV. Enantiomeric and diastereomeric dioxadrols: behavioral, biochemical and chemical determination of the configuration necessary for phencyclidine-like properties. J Pharmacol Exp Ther. 1987 Oct;243(1):110-7. PMID: 2822892.
4: Pechnick RN, Poland RE. Neuroendocrine responses produced by enantiomeric pairs of drugs that interact with phencyclidine and sigma receptors. Eur J Pharmacol. 1994 Sep 22;263(1-2):115-20. doi: 10.1016/0014-2999(94)90531-2. PMID: 7821343.
5: Brog JS, Beinfeld MC. Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists involves blockade of the muscarinic cholinergic receptor: a novel dioxadrol- preferring interaction. J Pharmacol Exp Ther. 1990 Sep;254(3):952-6. PMID: 2203900.
6: Berry SC, Anis NA, Lodge D. The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord. Brain Res. 1984 Jul 30;307(1-2):85-90. doi: 10.1016/0006-8993(84)90463-3. PMID: 6147179.
7: Mendelsohn LG, Kerchner GA, Kalra V, Zimmerman DM, Leander JD. Phencyclidine receptors in rat brain cortex. Biochem Pharmacol. 1984 Nov 15;33(22):3529-35. doi: 10.1016/0006-2952(84)90133-3. PMID: 6095851.
8: Harrison EA Jr, Rafferty MF, Rice KC, Creveling CR, Winger GD, Woods JH, Jacobson AE. Evidence for separation of anesthetic activity from prototypic phencyclidine action in drug discrimination by molecular modification of dioxadrol, a phencyclidine-like dissociative anesthetic. NIDA Res Monogr. 1984;55:90-6. PMID: 6100507.
9: Creveling CR, McNeal ET, Lewandowski GA, Rafferty M, Harrison EH, Jacobson AE, Rice KC, Daly JW. Local anesthetic properties of opioids and phencyclidines: interaction with the voltage-dependent, batrachotoxin binding site in sodium channels. Neuropeptides. 1985 Feb;5(4-6):253-6. doi: 10.1016/0143-4179(85)90026-5. PMID: 2582303.
10: ffrench-Mullen JM, Rogawski MA. Interaction of phencyclidine with voltage- dependent potassium channels in cultured rat hippocampal neurons: comparison with block of the NMDA receptor-ionophore complex. J Neurosci. 1989 Nov;9(11):4051-61. doi: 10.1523/JNEUROSCI.09-11-04051.1989. PMID: 2555461; PMCID: PMC6569947.
