MedKoo Cat#: 576470 | Name: Tropisetron

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tropisetron is an indole derivative and 5-HT3 receptor antagonist used for the prevention of nausea and vomiting.

Chemical Structure

Tropisetron
Tropisetron
CAS#89565-68-4

Theoretical Analysis

MedKoo Cat#: 576470

Name: Tropisetron

CAS#: 89565-68-4

Chemical Formula: C17H20N2O2

Exact Mass: 284.1525

Molecular Weight: 284.36

Elemental Analysis: C, 71.81; H, 7.09; N, 9.85; O, 11.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ICF 205-930; ICS 205930; Tropisetron
IUPAC/Chemical Name
1H-Indole-3-carboxylic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-
InChi Key
ZNRGQMMCGHDTEI-ITGUQSILSA-N
InChi Code
InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+
SMILES Code
CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c3c[nH]c4ccccc34
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 284.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ang SK, Shoemaker LK, Davis MP. Nausea and vomiting in advanced cancer. Am J Hosp Palliat Care. 2010 May;27(3):219-25. Epub 2010 Mar 2. PubMed PMID: 20197557. 2: Marcus DA. Fibromyalgia: diagnosis and treatment options. Gend Med. 2009;6 Suppl 2:139-51. PubMed PMID: 19406366. 3: Fujii Y. Current management of vomiting after tonsillectomy in children. Curr Drug Saf. 2009 Jan;4(1):62-73. Review. PubMed PMID: 19149526. 4: Fujii Y. The benefits and risks of different therapies in preventing postoperative nausea and vomiting in patients undergoing thyroid surgery. Curr Drug Saf. 2008 Jan;3(1):27-34. Review. PubMed PMID: 18690978. 5: Reddy GK, Gralla RJ, Hesketh PJ. Novel neurokinin-1 antagonists as antiemetics for the treatment of chemotherapy-induced emesis. Support Cancer Ther. 2006 Apr 1;3(3):140-2. PubMed PMID: 18632487. 6: Di Maio M, Gallo C, Perrone F. [Meta-analysis of phase III studies with palonosetron in the prevention of vomiting induced by moderately emetogenic chemotherapy]. Tumori. 2008 Mar-Apr;94(2):suppl 14-22. Italian. PubMed PMID: 18564621. 7: Harten P. [Fibromyalgia syndrome: new developments in pharmacotherapy]. Z Rheumatol. 2008 Feb;67(1):75-82. Review. German. PubMed PMID: 17924124. 8: Leung AK, Robson WL. Acute gastroenteritis in children: role of anti-emetic medication for gastroenteritis-related vomiting. Paediatr Drugs. 2007;9(3):175-84. Review. PubMed PMID: 17523698. 9: Jordan K, Hinke A, Grothey A, Voigt W, Arnold D, Wolf HH, Schmoll HJ. A meta-analysis comparing the efficacy of four 5-HT3-receptor antagonists for acute chemotherapy-induced emesis. Support Care Cancer. 2007 Sep;15(9):1023-33. Epub 2007 Jan 5. PubMed PMID: 17205281. 10: Neufeld SM, Newburn-Cook CV. The efficacy of 5-HT3 receptor antagonists for the prevention of postoperative nausea and vomiting after craniotomy: a meta-analysis. J Neurosurg Anesthesiol. 2007 Jan;19(1):10-7. Review. PubMed PMID: 17198095.