IUPAC/Chemical Name
4-Dimethylamino-5-nitro-N-2-methoxy-diethylaminoethylbenzamide hydrochloride
InChi Key
BKNHIEXEGTYQHO-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H26N4O4.ClH/c1-7-18(8-2)19(9-3)16(21)12-10-14(20(22)23)13(17(4)5)11-15(12)24-6;/h10-11H,7-9H2,1-6H3;1H
SMILES Code
O=C(N(CC)N(CC)CC)C1=CC([N+]([O-])=O)=C(N(C)C)C=C1OC.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
374.87
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Legeza VI, Shagoian MG, Martirosov KS, Kamynina MF, Markovskaia IV. Issledovanie protivorvotnoĭ aktivnosti dimetpramida [Antiemetic activity of dimetpramid]. Farmakol Toksikol. 1984 Sep-Oct;47(5):55-9. Russian. PMID: 6542025.
2: Orlova TM, Tsarichenko GV, Malochkin VV, Legeza VI, Shagoian MG. Toksichnost' original'nogo protivorvotnogo preparata dimetpramida [Toxicity of an original antiemetic preparation dimetpramid]. Farmakol Toksikol. 1985 Nov-Dec;48(6):74-6. Russian. PMID: 4085635.
3: Legeza VI, Kamynina MF, Markovskaia IV, Shagoian MG, Martirosov KS. Vliianie dimetpramida i metoklopramida na skorost' oborota katekholaminov v podkorkovo- stvolovykh strukturakh golovnogo mozga krys [Effect of dimetpramid and metoclopramide on the rate of catecholamine turnover in the subcortical-stem structures of the rat brain]. Farmakol Toksikol. 1986 Jul-Aug;49(4):25-7. Russian. PMID: 3019759.
4: Rakhmilevich BM, Simbirtseva LP, Varshamov IuL, Shagoian MG, Legeza VI. Primenenie dimetpramida dlia profilaktiki i lecheniia neĭrotoksicheskikh reaktsiĭ pri luchevoĭ i khimioterapii bol'nykh limfogranulematozom [Use of dimetpramid for the prevention and treatment of neurotoxic reactions during radio- and chemotherapy of lymphogranulomatosis]. Med Radiol (Mosk). 1983 Jan;28(1):16-8. Russian. PMID: 6827928.
5: Orlova TM, Malochkin VV, Tsarichenko GV, Legeza VI, Shagoian MG. Vliianie protivorvotnogo preparata dimetpramida na reproduktivnuiu funktsiiu krys [Effect of the antiemetic preparation dimetpramid on rat reproductive function]. Farmakol Toksikol. 1985 Jan-Feb;48(1):62-6. Russian. PMID: 4038947.
6: Martirosov KS, Grigor'ev IuG, Zorin VV, Andrianova IE. Eksperimental'noe izuchenie roli blokady 5-HT3-retseptorov serotonina i D2-retseptorov dofamina v mekhanizme vozniknoveniia ranneĭ radiatsionnoĭ rvoty u obez'ian [An experimental study of the role of a blockade of serotonin 5-HT3 receptors and dopamine D2 receptors in the mechanism of the occurrence of early radiation vomiting in monkeys]. Radiats Biol Radioecol. 2000 May-Jun;40(3):277-80. Russian. PMID: 10907404.
7: Martirosov KS, Grigor'ev IuG, Borovkov MV, Zorin VV. Eksperimental'noe izuchenie roli blokady 5-HT3-retseptorov serotonina i D2-retseptorov dofamina v mekhanizme vozniknoveniia ranneĭ radiatsionnoĭ rvoty u sobak [Experimental study of the role of blocking 5-HT3-receptors of serotonin and D2-receptors of dopamine in the mechanism of early radiation vomiting in dogs]. Radiats Biol Radioecol. 2002 Jan-Feb;42(1):75-9. Russian. PMID: 11898636.
8: Martirosov KS, Grigor'ev IuG, Zorin VV, Norkin IM. O mekhanizme vozniknoveniia rvoty v periode pervichnoĭ reaktsii posle vozdeĭstviia na organizm ioniziruiushchakh izlucheniĭ v bol'shakh dozakh [The mechanism of the occurrence of vomiting during the primary reaction after exposure of the body to ionizing radiations at large doses]. Radiats Biol Radioecol. 1997 May- Jun;37(3):343-9. Russian. PMID: 9244521.
9: Martirosov KS, Grigor'ev IuG, Zorin VV, Iashkin PN. Eksperimental'noe izuchenie roli prostaglandinov v mekhanizme vozniknoveniia dispepticheskikh narusheniĭ v period pervichnoĭ reaktsii posle vozdeĭstviia na organizm ioniziruiushchikh izlucheniĭ v bol'shikh dozakh [An experimental study of the role of prostaglandins in the mechanism of the occurrence of dyspeptic disorders during the primary reaction after body exposure to ionizing radiation at large doses]. Radiats Biol Radioecol. 2000 May-Jun;40(3):272-6. Russian. PMID: 10907403.
10: Martirosov KS, Grigor'ev IuG, Zorin VV, Iashkin PN. O mekhanizme vozniknoveniia dispepsicheskikh narusheniĭ v period pervichnoĭ reaktsii posle vozdeĭstviia na organizm ioniziruiushchikh izlucheniĭ v bol'shikh dozakh [Mechanism of the etiology of dyspeptic disorders during the period of primary reaction after exposure to high-dose ionizing radiation]. Radiats Biol Radioecol. 1998 Nov-Dec;38(6):819-25. Russian. PMID: 9889776.
