Synonym
Diphezyl; Difezil; G-472-b
IUPAC/Chemical Name
N-(3-acetyl-5-chloro-2-hydroxybenzyl)-N,N-dimethyl-2-phenoxyethan-1-aminium 3-hydroxy-2-naphthoate
InChi Key
YUEVPNYAMMPISG-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H22ClNO3.C11H8O3/c1-14(22)18-12-16(20)11-15(19(18)23)13-21(2,3)9-10-24-17-7-5-4-6-8-17;12-10-6-8-4-2-1-3-7(8)5-9(10)11(13)14/h4-8,11-12H,9-10,13H2,1-3H3;1-6,12H,(H,13,14)
SMILES Code
CC(c1c(O)c(C[N+](C)(CCOc2ccccc2)C)cc(Cl)c1)=O.Oc(c3)c(C([O-])=O)cc4c3cccc4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
536.02
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kharitonova SI, Kosheleva LI, Shumakovich IE, Kolesova VS. Kolichestvennoe opredelenie difezila [Quantitative determination of diphezyl]. Farmatsiia. 1973 Jul-Aug;22(4):51-4. Russian. PMID: 4754250.
2: Krotov AI, Konopleva TK, Braude MB, Bekhli AF. Difezil - novyĭ antgel'mintik dlia terapii trikhotsefaleza [Diphezyl--a new antihelminthic drug for the therapy of trichocephaliasis]. Med Parazitol (Mosk). 1969 Jan-Feb;38(1):80-4. Russian. PMID: 5371115.
3: Sergacheva IuIu, Sokhanenkova TL, Naĭdenova AS. Deĭstvie antigel'mintikov difezila i bemosata na kholinésteraznuiu aktivnost' vlasoglavov i mysheĭ v opytakh in vivo [Action of the anthelmintics difezil and bemosat on the cholinesterase activity of whipworms and mice in vivo experiments]. Med Parazitol (Mosk). 1982 Nov-Dec;51(6):34-7. Russian. PMID: 7155061.
4: Karnaukhov VK, Ozeretskovskaia NN, Firsova RA, Shcherbakov AM, Laskovenko AI. Sravnitel'naia éffektivnost' i perenosimost' difezila, bermoksa i pirantela pri lechenii bol'nykh kishechnymi nematodozami [Comparative effectiveness and tolerance for difezil, bermoks and pyrantel in treating intestinal nematodiases]. Sov Med. 1980;(11):117-20. Russian. PMID: 7444636.
5: Abdulazizov. Gistokhimicheskoe opredelenie gidroliticheskikh fermentov v organakh mysheĭ, zarazhennykh Trichocephalus muris (Schrank, 1788) pri lechenil ikh difezilom [Histochemical determination of hydrolytic enzymes in the bodies of mice infected with Trichocephalus muris (Schrank, 1788) during treatment with difezil]. Med Parazitol (Mosk). 1980 Jul-Aug;49(4):690-72. Russian. PMID: 7421741.
