Synonym
Ethyl biscoumacetate; Pelentan; Trombarin; Neodicumarinum; Neodicumarol; NSC36366; NSC-36366; NSC 36366
IUPAC/Chemical Name
2H-1-Benzopyran-3-acetic acid, 4-hydroxy-alpha-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-2-oxo-, ethyl ester (9CI)
InChi Key
JCLHQFUTFHUXNN-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H16O8/c1-2-28-20(25)15(16-18(23)11-7-3-5-9-13(11)29-21(16)26)17-19(24)12-8-4-6-10-14(12)30-22(17)27/h3-10,15,23-24H,2H2,1H3
SMILES Code
O=C(OCC)C(C1=C(O)C2=CC=CC=C2OC1=O)C3=C(O)C4=CC=CC=C4OC3=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
408.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Perlík F, Patzelová V. Pharmacokinetics of ethyl biscoumacetate and its metabolite 7-hydroxy ethyl biscoumacetate in healthy volunteers. Int J Clin Pharmacol Ther. 1994 Nov;32(11):622-4. PMID: 7874379.
2: Gimeno A, Mestres-Truyol J, Ojeda-Montes MJ, Macip G, Saldivar-Espinoza B, Cereto-Massagué A, Pujadas G, Garcia-Vallvé S. Prediction of Novel Inhibitors of the Main Protease (M-pro) of SARS-CoV-2 through Consensus Docking and Drug Reposition. Int J Mol Sci. 2020 May 27;21(11):3793. doi: 10.3390/ijms21113793. PMID: 32471205; PMCID: PMC7312484.
3: Garrettson LK, Perel JM, Dayton PG. Methylphenidate interaction with both anticonvulsants and ethyl biscoumacetate. JAMA. 1969 Mar 17;207(11):2053-6. PMID: 5818377.
4: ILLINGWORTH RS, FINCH E. Ethyl biscoumacetate (tromexan) in human milk. J Obstet Gynaecol Br Emp. 1959 Jun;66:487-8. doi: 10.1111/j.1471-0528.1959.tb02065.x. PMID: 13852719.
5: Copie X, Pinquier JL, Letrait M, Paltiat MH, Pello JY, Rey E, Chanteclair G, de Lauture D, Olive G, Strauch G. Effet du diméticone sur la pharmacocinétique et la pharmacodynamie du biscoumacétate d'éthyle [Effect of dimethicone on pharmacokinetics and pharmacodynamics of ethyl biscoumacetate]. Therapie. 1993 Mar-Apr;48(2):119-23. French. PMID: 8351679.
6: BEAMISH RE. ANTICOAGULANTS. Can Med Assoc J. 1965 Jul 3;93(1):33-4. PMID: 14313622; PMCID: PMC1928636.
7: Pospísil J, Patzelová V, Perlík F. Determination of ethyl biscoumacetate and its metabolite 7-hydroxyethyl biscoumacetate in human serum by high-performance liquid chromatography and mass spectrometry. J Chromatogr. 1992 Feb 7;574(1):71-5. doi: 10.1016/0378-4347(92)80099-c. PMID: 1629290.
8: BURNS JJ, WEINER M, SIMSON G, BRODIE BB. The biotransformation of ethyl biscoumacetate (tromexan) in man, rabbit and dog. J Pharmacol Exp Ther. 1953 May;108(1):33-41. PMID: 13053419.
9: BRODIE BB, WEINER M, BURNS JJ, SIMSON G, YALE EK. The physiological disposition of ethyl biscoumacetate (tromexan) in man and a method for its estimation in biological material. J Pharmacol Exp Ther. 1952 Dec;106(4):453-63. PMID: 13023556.
10: Sharaev PN, Bogdanov NG, Nurkaeva AT. The effects of menadione, ethyl biscoumacetate, and sodium salicylate on the metabolism of mucopolysaccharides in the aortic wall and liver of rats. Cor Vasa. 1977;19(2):151-5. PMID: 143357.
