Synonym
Pyridindolol; NSC 266530; NSC266530 NSC-266530;
IUPAC/Chemical Name
(R)-1-(3-(hydroxymethyl)-9H-pyrido[3,4-b]indol-1-yl)ethane-1,2-diol
InChi Key
VAKXHGQDPLEUTH-LBPRGKRZSA-N
InChi Code
InChI=1S/C14H14N2O3/c17-6-8-5-10-9-3-1-2-4-11(9)16-13(10)14(15-8)12(19)7-18/h1-5,12,16-19H,6-7H2/t12-/m0/s1
SMILES Code
OC[C@H](O)C1=C2C(C3=CC=CC=C3N2)=CC(CO)=N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
258.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Iorio M, Davatgarbenam S, Serina S, Criscenzo P, Zdouc MM, Simone M, Maffioli SI, Ebright RH, Donadio S, Sosio M. Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain. Sci Rep. 2021 Mar 12;11(1):5827. doi: 10.1038/s41598-021-84833-2. PMID: 33712632; PMCID: PMC7955054.
2: Kanekiyo N, Kuwada T, Choshi T, Nobuhiro J, Hibino S. Total syntheses of beta-carboline alkaloids, (R)-(-)-pyridindolol K1, (R)-(-)-pyridindolol K2, and (R)-(-)-pyridindolol. J Org Chem. 2001 Dec 28;66(26):8793-8. doi: 10.1021/jo0105585. PMID: 11749608.
3: Kim YP, Takamatsu S, Hayashi M, Komiyama K, Omura S. Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711. J Antibiot (Tokyo). 1997 Mar;50(3):189-93. PMID: 9439688.
4: Kim YP, Takamatsu S, Hayashi M, Komiyama K, Omura S. Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711. J Antibiot (Tokyo). 1997 Mar;50(3):189-93. PMID: 9127188.
5: Hagmann L, Keller-Schierlein W, Wahl B, Zähner H. Metabolites of microorganisms. 242 pyridindolol glucosides from Streptomyces parvulus. J Antibiot (Tokyo). 1988 Mar;41(3):289-95. doi: 10.7164/antibiotics.41.289. PMID: 3366687.
6: Kumagai M, Aoyagi T, Umezawa H. Inhibitory activity of pyridindolol on beta- galactosidase. J Antibiot (Tokyo). 1976 Jul;29(7):696-703. doi: 10.7164/antibiotics.29.696. PMID: 8415.
7: Kumagai M, Naganawa H, Aoyagi T, Umezawa H. Structure of pyridindolol, inhibitor of beta-galactosidase. J Antibiot (Tokyo). 1975 Nov;28(11):876-80. doi: 10.7164/antibiotics.28.876. PMID: 1201971.
8: Aoyagi T, Kumagai M, Hazato T, Hamada M, Takeuchi T. Pyridindolol, a new beta-galactosidase inhibitor produced by actinomycetes. J Antibiot (Tokyo). 1975 Jul;28(7):555-7. doi: 10.7164/antibiotics.28.555. PMID: 1150547.
