LSN3318839 is an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide‑1 Receptor. LSN3318839 increases the potency and efficacy of the weak metabolite GLP-1(9-36)NH2 to become a full agonist at the GLP-1R and modestly potentiates the activity of the highly potent full-length ligand, GLP-1(7-36)NH2. LSN3318839 preferentially enhances G protein-coupled signaling by the GLP-1R over β-arrestin recruitment. LSN3318839 demonstrates robust glucose lowering in animal models alone or in treatment combination with sitagliptin.
MedKoo Cat#: 464397
Name: LSN3318839
CAS#: 2764704-18-7
Chemical Formula: C26H23Cl2N3O2
Exact Mass: 479.1167
Molecular Weight: 480.39
Elemental Analysis: C, 65.01; H, 4.83; Cl, 14.76; N, 8.75; O, 6.66
The following data is based on the product molecular weight 480.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
