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MedKoo Cat#: 555967 | Name: Conoidin A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Conoidin A inactivates peroxiredoxins by covalently binding to the catalytic cysteine on the enzyme.

Chemical Structure

Conoidin A
CAS#18080-67-6

Theoretical Analysis

MedKoo Cat#: 555967

Name: Conoidin A

CAS#: 18080-67-6

Chemical Formula: C10H8Br2N2O2

Exact Mass: 345.8953

Molecular Weight: 347.99

Elemental Analysis: C, 34.51; H, 2.32; Br, 45.92; N, 8.05; O, 9.19

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 2 Weeks
200mg USD 550.00 2 Weeks
500mg USD 1,250.00 2 Weeks
1g USD 2,250.00 2 Weeks
2g USD 4,250.00 2 Weeks
5g USD 6,450.00 2 Weeks
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Related CAS #
No Data
Synonym
Conoidin A
IUPAC/Chemical Name
2,3-bis(bromomethyl)-quinoxaline 1,4-dioxide
InChi Key
DQKNFTLRMZOAMG-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H8Br2N2O2/c11-5-9-10(6-12)14(16)8-4-2-1-3-7(8)13(9)15/h1-4H,5-6H2
SMILES Code
BrCC1=C(CBr)[N+]([O-])=C2C=CC=CC2=[N+]1[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 347.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Szeliga M, Rola R. Conoidin A, a Covalent Inhibitor of Peroxiredoxin 2, Reduces Growth of Glioblastoma Cells by Triggering ROS Production. Cells. 2023 Jul 26;12(15):1934. doi: 10.3390/cells12151934. PMID: 37566013; PMCID: PMC10417327. 2: Haraldsen JD, Liu G, Botting CH, Walton JG, Storm J, Phalen TJ, Kwok LY, Soldati-Favre D, Heintz NH, Müller S, Westwood NJ, Ward GE. IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem. 2009;7:3040-3048. doi: 10.1039/B901735F. PMID: 21359112; PMCID: PMC3043594. 3: Liu G, Botting CH, Evans KM, Walton JA, Xu G, Slawin AM, Westwood NJ. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem. 2010 Jan;5(1):41-5. doi: 10.1002/cmdc.200900391. PMID: 19946931. 4: Nguyen JB, Pool CD, Wong CY, Treger RS, Williams DL, Cappello M, Lea WA, Simeonov A, Vermeire JJ, Modis Y. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chem Biol. 2013 Aug 22;20(8):991-1001. doi: 10.1016/j.chembiol.2013.06.011. Epub 2013 Jul 25. PMID: 23891152; PMCID: PMC3755041. 5: Ryu DY, Kim KU, Kwon WS, Rahman MS, Khatun A, Pang MG. Peroxiredoxin activity is a major landmark of male fertility. Sci Rep. 2017 Dec 7;7(1):17174. doi: 10.1038/s41598-017-17488-7. PMID: 29215052; PMCID: PMC5719347. 6: Tilley LD, Krishnamurthy S, Westwood NJ, Ward GE. Identification of TgCBAP, a novel cytoskeletal protein that localizes to three distinct subcompartments of the Toxoplasma gondii pellicle. PLoS One. 2014 Jun 2;9(6):e98492. doi: 10.1371/journal.pone.0098492. PMID: 24887026; PMCID: PMC4041824. 7: Tan X, Chen J, Keep RF, Xi G, Hua Y. Prx2 (Peroxiredoxin 2) as a Cause of Hydrocephalus After Intraventricular Hemorrhage. Stroke. 2020 May;51(5):1578-1586. doi: 10.1161/STROKEAHA.119.028672. Epub 2020 Apr 13. PMID: 32279622; PMCID: PMC7192237. 8: Jeon HJ, Park YS, Cho DH, Kim JS, Kim E, Chae HZ, Chun SY, Oh JS. Peroxiredoxins are required for spindle assembly, chromosome organization, and polarization in mouse oocytes. Biochem Biophys Res Commun. 2017 Jul 22;489(2):193-199. doi: 10.1016/j.bbrc.2017.05.127. Epub 2017 May 25. PMID: 28552528. 9: Jang YJ, Kim JS, Yun PR, Seo YW, Lee TH, Park JI, Chun SY. Involvement of peroxiredoxin 2 in cumulus expansion and oocyte maturation in mice. Reprod Fertil Dev. 2020 May;32(8):783-791. doi: 10.1071/RD19310. PMID: 32389179. 10: Brizuela M, Huang HM, Smith C, Burgio G, Foote SJ, McMorran BJ. Treatment of erythrocytes with the 2-cys peroxiredoxin inhibitor, Conoidin A, prevents the growth of Plasmodium falciparum and enhances parasite sensitivity to chloroquine. PLoS One. 2014 Apr 3;9(4):e92411. doi: 10.1371/journal.pone.0092411. PMID: 24699133; PMCID: PMC3974718. 11: Vivoli A, Ghislain J, Filali-Mouhim A, Angeles ZE, Castell AL, Sladek R, Poitout V. Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid-Induced Rat β-Cell Proliferation. Diabetes. 2023 Jan 1;72(1):45-58. doi: 10.2337/db22-0121. PMID: 36191509; PMCID: PMC9797324. 12: Bian L, Zhang J, Wang M, Keep RF, Xi G, Hua Y. Intracerebral Hemorrhage- Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2. Transl Stroke Res. 2020 Apr;11(2):288-295. doi: 10.1007/s12975-019-00714-x. Epub 2019 Jul 4. Erratum in: Transl Stroke Res. 2019 Aug 9;: PMID: 31273681; PMCID: PMC6942235. 13: Stancill JS, Happ JT, Broniowska KA, Hogg N, Corbett JA. Peroxiredoxin 1 plays a primary role in protecting pancreatic β-cells from hydrogen peroxide and peroxynitrite. Am J Physiol Regul Integr Comp Physiol. 2020 May 1;318(5):R1004-R1013. doi: 10.1152/ajpregu.00011.2020. Epub 2020 Apr 15. PMID: 32292063; PMCID: PMC7272767. 14: Specker G, Estrada D, Radi R, Piacenza L. Trypanosoma cruzi Mitochondrial Peroxiredoxin Promotes Infectivity in Macrophages and Attenuates Nifurtimox Toxicity. Front Cell Infect Microbiol. 2022 Feb 4;12:749476. doi: 10.3389/fcimb.2022.749476. PMID: 35186785; PMCID: PMC8855072. 15: Bai Y, Liang C, Zhou J, Liu Y, Wang F, Gao J, Wu J, Hu D. Development of novel celastrol-ligustrazine hybrids as potent peroxiredoxin 1 inhibitors against lung cancer. Eur J Med Chem. 2023 Nov 5;259:115656. doi: 10.1016/j.ejmech.2023.115656. Epub 2023 Jul 17. PMID: 37499289. 16: Mostek-Majewska A, Janta A, Majewska A, Ciereszko A. Effect of 2-Cys Peroxiredoxins Inhibition on Redox Modifications of Bull Sperm Proteins. Int J Mol Sci. 2021 Nov 28;22(23):12888. doi: 10.3390/ijms222312888. PMID: 34884692; PMCID: PMC8657687. 17: Feng T, Zhao R, Sun F, Lu Q, Wang X, Hu J, Wang S, Gao L, Zhou Q, Xiong X, Dong X, Wang L, Han B. TXNDC9 regulates oxidative stress-induced androgen receptor signaling to promote prostate cancer progression. Oncogene. 2020 Jan;39(2):356-367. doi: 10.1038/s41388-019-0991-3. Epub 2019 Sep 2. PMID: 31477836. 18: Olson KR, Gao Y. Effects of inhibiting antioxidant pathways on cellular hydrogen sulfide and polysulfide metabolism. Free Radic Biol Med. 2019 May 1;135:1-14. doi: 10.1016/j.freeradbiomed.2019.02.011. Epub 2019 Feb 19. PMID: 30790656. 19: Yaakoub H, Staerck C, Mina S, Godon C, Fleury M, Bouchara JP, Calenda A. Repurposing of auranofin and honokiol as antifungals against Scedosporium species and the related fungus Lomentospora prolificans. Virulence. 2021 Dec;12(1):1076-1090. doi: 10.1080/21505594.2021.1909266. PMID: 33825667; PMCID: PMC8032236. 20: Tam KC, Ali E, Hua J, Chataway T, Barritt GJ. Evidence for the interaction of peroxiredoxin-4 with the store-operated calcium channel activator STIM1 in liver cells. Cell Calcium. 2018 Sep;74:14-28. doi: 10.1016/j.ceca.2018.05.002. Epub 2018 May 15. PMID: 29804005.