Dicentrinone | CAS# 16408-78-9 | antioxidant, anti-rheumatic, anti-inflammatory, an antitrypanosomal

MedKoo Cat#: 413687 | Name: Dicentrinone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dicentrinone is an antioxidant, anti-rheumatic, anti-inflammatory, an antitrypanosomal

Chemical Structure

Dicentrinone

CAS#16408-78-9

Theoretical Analysis

MedKoo Cat#: 413687

Name: Dicentrinone

CAS#: 16408-78-9

Chemical Formula: C19H13NO5

Exact Mass: 335.0794

Molecular Weight: 335.32

Elemental Analysis: C, 68.06; H, 3.91; N, 4.18; O, 23.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Dicentrinone; NSC617671; NSC-617671; NSC 617671

IUPAC/Chemical Name

8H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinolin-8-one, 10,11-dimethoxy-

InChi Key

NEQVOBXBOFZEMR-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H13NO5/c1-22-12-6-10-11(7-13(12)23-2)18(21)17-15-9(3-4-20-17)5-14-19(16(10)15)25-8-24-14/h3-7H,8H2,1-2H3

SMILES Code

O=C1C2=CC(OC)=C(OC)C=C2C3=C4OCOC4=CC5=CC=NC1=C53

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 335.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Barbosa H, da Silva RLCG, Costa-Silva TA, Tempone AG, Antar GM, Lago JHG, Caseli L. Interaction of dicentrinone, an antitrypanosomal aporphine alkaloid isolated from Ocotea puberula (Lauraceae), in cell membrane models at the air- water interface. Bioorg Chem. 2020 Aug;101:103978. doi: 10.1016/j.bioorg.2020.103978. Epub 2020 Jun 1. PMID: 32534347. 2: do Santos RC, de Souza AV, Andrade-Silva M, Vera Cruz KC, Leite Kassuya CA, Lima Cardoso CA, Vieira MDC, Nazari Formagio AS. Antioxidant, anti-rheumatic and anti-inflammatory investigation of extract and dicentrinone from Duguetia furfuracea (A. St.-Hil.) Benth. & Hook. f. J Ethnopharmacol. 2018 Jan 30;211:9-16. doi: 10.1016/j.jep.2017.09.019. Epub 2017 Sep 21. PMID: 28942134. 3: Chanakul W, Tuchinda P, Anantachoke N, Pohmakotr M, Piyachaturawat P, Jariyawat S, Suksen K, Jaipetch T, Nuntasaen N, Reutrakul V. Cytotoxic alkaloids from stems, leaves and twigs of Dasymaschalon blumei. Fitoterapia. 2011 Oct;82(7):964-8. doi: 10.1016/j.fitote.2011.05.012. Epub 2011 May 27. PMID: 21641972. 4: Barinas JA, Suárez LE. Chemical constituents of Talauma arcabucoana (Magnoliaceae): their brine shrimp lethality and antimicrobial activity. Nat Prod Res. 2011 Sep;25(16):1497-504. doi: 10.1080/14786410903205146. Epub 2011 Jul 8. PMID: 21347974. 5: Zhou BN, Johnson RK, Mattern MR, Wang X, Hecht SM, Beck HT, Ortiz A, Kingston DG. Isolation and biochemical characterization of a new topoisomerase I inhibitor from Ocotea leucoxylon. J Nat Prod. 2000 Feb;63(2):217-21. doi: 10.1021/np990442s. PMID: 10691712. 6: Yu R, Li BG, Ye Q, Zhang GL. A novel alkaloid from Mitrephora maingayi. Nat Prod Res. 2005 Jun;19(4):359-62. doi: 10.1080/14786410412331280104. PMID: 15938142. 7: Hu J, Shi X, Chen J, Mao X, Zhu L, Yu L, Shi J. Alkaloids from Toddalia asiatica and their cytotoxic, antimicrobial and antifungal activities. Food Chem. 2014 Apr 1;148:437-44. doi: 10.1016/j.foodchem.2012.12.058. PMID: 24262580. 8: da Silva DB, Tulli EC, Militão GC, Costa-Lotufo LV, Pessoa C, de Moraes MO, Albuquerque S, de Siqueira JM. The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea. Phytomedicine. 2009 Nov;16(11):1059-63. doi: 10.1016/j.phymed.2009.03.019. Epub 2009 May 7. PMID: 19423311. 9: Vecchietti V, Casagrande C, Ferrari G, Severini Ricca G. New aporphine alkaloids of Ocotea minarum. Farmaco Sci. 1979 Oct;34(10):829-40. PMID: 510527. 10: Camacho MR, Kirby GC, Warhurst DC, Croft SL, Phillipson JD. Oxoaporphine alkaloids and quinones from Stephania dinklagei and evaluation of their antiprotozoal activities. Planta Med. 2000 Jun;66(5):478-80. doi: 10.1055/s-2000-8597. PMID: 10909274.