HSD-016 | CAS# 946396-92-5 | 11β-HSD1 inhibitor

MedKoo Cat#: 576394 | Name: HSD-016

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HSD-016 is a potent, selective, and efficacious 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor.

Chemical Structure

HSD-016

CAS#946396-92-5

Theoretical Analysis

MedKoo Cat#: 576394

Name: HSD-016

CAS#: 946396-92-5

Chemical Formula: C21H21F7N2O3S

Exact Mass: 514.1161

Molecular Weight: 514.46

Elemental Analysis: C, 49.03; H, 4.11; F, 25.85; N, 5.45; O, 9.33; S, 6.23

Price and Availability

Size	Price	Availability
1mg	USD 90.00	Ready to ship
5mg	USD 350.00	Ready to ship
10mg	USD 550.00	Ready to ship
25mg	USD 1,250.00	Ready to ship
50mg	USD 1,950.00	Ready to ship
100mg	USD 2,950.00	Ready to ship

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Related CAS #

No Data

Synonym

HSD-016; HSD 016; HSD016; HSD-16; HSD 16; HSD16;

IUPAC/Chemical Name

(R)-1,1,1-trifluoro-2-(3-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)phenyl)propan-2-ol

InChi Key

ZWASRJHIEFYJGL-BFUOFWGJSA-N

InChi Code

InChI=1S/C21H21F7N2O3S/c1-13-12-29(18-7-6-15(22)11-17(18)20(23,24)25)8-9-30(13)34(32,33)16-5-3-4-14(10-16)19(2,31)21(26,27)28/h3-7,10-11,13,31H,8-9,12H2,1-2H3/t13-,19-/m1/s1

SMILES Code

O[C@](C(F)(F)F)(C)C1=CC=CC(S(=O)(N2[C@H](C)CN(C3=CC=C(F)C=C3C(F)(F)F)CC2)=O)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot# T21D12P17

QC Data

View QC data: current batch, Lot# T21D12P17

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

(R)-1,1,1-trifluoro-2-(3-((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)propan-2-ol (HSD-016) was discovered to be a potent, selective, and efficacious 11β-HSD1 inhibitor and advanced as a clinical candidate.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	0.0	0.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 514.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1. Wan ZK, Chenail E, Li HQ, Kendall C, Wang Y, Gingras S, Xiang J, Massefski WW, Mansour TS, Saiah E. Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016. J Org Chem. 2011 Sep 2;76(17):7048-55. doi: 10.1021/jo200958a. Epub 2011 Aug 2. PMID: 21736359.