Synonym
HSP-117 dihydrochloride; HSP 117 dihydrochloride; HSP117 dihydrochloride
IUPAC/Chemical Name
3-Piperidinamine, N-((2,3-dihydro-5-(1-methylethyl)-7-benzofuranyl)methyl)-2-phenyl-, dihydrochloride, (2S-cis)-
InChi Key
GEMYTIALOXZOQO-IXOXMDGESA-N
InChi Code
InChI=1S/C23H30N2O.2ClH/c1-16(2)19-13-18-10-12-26-23(18)20(14-19)15-25-21-9-6-11-24-22(21)17-7-4-3-5-8-17;;/h3-5,7-8,13-14,16,21-22,24-25H,6,9-12,15H2,1-2H3;2*1H/t21-,22-;;/m0../s1
SMILES Code
Cl.Cl.CC(C)c1cc(CN[C@H]2CCCN[C@H]2c3ccccc3)c4OCCc4c1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
423.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Saeki M, Sakai M, Saito R, Kubota H, Ariumi H, Takano Y, Yamatodani A, Kamiya H. Effects of HSP-117, a novel tachykinin NK1-receptor antagonist, on cisplatin-induced pica as a new evaluation of delayed emesis in rats. Jpn J Pharmacol. 2001 Jul;86(3):359-62. doi: 10.1254/jjp.86.359. PMID: 11488439.
2. Saito R, Suehiro Y, Ariumi H, Migita K, Hori N, Hashiguchi T, Sakai M, Saeki M, Takano Y, Kamiya H. Anti-emetic effects of a novel NK-1 receptor antagonist HSP-117 in ferrets. Neurosci Lett. 1998 Oct 2;254(3):169-72. doi: 10.1016/s0304-3940(98)00682-x. PMID: 10214984.
