Synonym
HP-184; HP184; HP 184; Nerispirdine
IUPAC/Chemical Name
1H-Indol-1-amine, N-(3-fluoro-4-pyridinyl)-3-methyl-N-propyl-
InChi Key
BTDHTARYCBHHPJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H18FN3/c1-3-10-20(17-8-9-19-11-15(17)18)21-12-13(2)14-6-4-5-7-16(14)21/h4-9,11-12H,3,10H2,1-2H3
SMILES Code
CCCN(c1ccncc1F)n2cc(C)c3ccccc23
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
283.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Schofield J, Derdau V, Atzrodt J, Zane P, Guo Z, van Horn R, Czepczor V, Stoltz A, Pardon M. Effect of deuteration on metabolism and clearance of Nerispirdine (HP184) and AVE5638. Bioorg Med Chem. 2015 Jul 1;23(13):3831-42. doi: 10.1016/j.bmc.2015.03.065. PubMed PMID: 25900628.
2: Smith C, Kongsamut S, Wang H, Ji J, Kang J, Rampe D. In Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin Exp Pharmacol Physiol. 2009 Nov;36(11):1104-9. doi: 10.1111/j.1440-1681.2009.05200.x. PubMed PMID: 19413590.
3: Smith CP, Woods-Kettelberger AT, Corbett R, Chesson SM, Bores GM, Petko WW, Roehr JE, Kongsamut S. Serotonergic activity of HP 184: does spontaneous release have a role? Neurochem Res. 1996 May;21(5):575-83. PubMed PMID: 8726966.
4: Tang L, Kongsamut S. Frequency-dependent inhibition of neurotransmitter release by besipirdine and HP 184. Eur J Pharmacol. 1996 Apr 4;300(1-2):71-4. PubMed PMID: 8741167.
