MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 464378 | Name: Ronidazole
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ronidazole is an antiprotozoal agent used in veterinary medicine for the treatment of histomoniasis and swine dysentery. It may also have use for the treatment of Tritrichomonas foetus infection in cats.

Chemical Structure

Ronidazole
Ronidazole
CAS#7681-76-7

Theoretical Analysis

MedKoo Cat#: 464378

Name: Ronidazole

CAS#: 7681-76-7

Chemical Formula: C6H8N4O4

Exact Mass: 200.0546

Molecular Weight: 200.15

Elemental Analysis: C, 36.01; H, 4.03; N, 27.99; O, 31.97

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Ronidazole; Ridazole; Dugro; Ridzol; Ronidazol;
IUPAC/Chemical Name
(1-methyl-5-nitro-1H-imidazol-2-yl)methyl carbamate
InChi Key
PQFRTXSWDXZRRS-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11)
SMILES Code
Cn1c([N+]([O-])=O)cnc1COC(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO and DMF
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Ronidazole is active against a panel of T. foetus isolates with minimum lethal concentrations (MLCs) ranging from 0.625 to 1.25 µg/ml. Ronidazole is active against C. difficile bacteria (MIC90 = 0.125 µg/ml). Ronidazole inhibits infection relapse in a cat model of experimental T. foetus infection.
In vitro activity:
To be determined
In vivo activity:
Ronidazole merits further investigation as a potential treatment for clostridioides difficile infections. Ronidazole did not inhibit growth of several commensal organisms naturally present in the human intestine that play a protective role in preventing clostridioides difficile infections. Ronidazole was found to be non-toxic to human gut cells. Reference: Int J Antimicrob Agents. 2020 Dec;56(6):106188. https://pubmed.ncbi.nlm.nih.gov/33045352/
Solvent mg/mL mM
Solubility
DMF 30.0 149.89
DMSO 30.0 149.89
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 200.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. AbdelKhalek A, Seleem MN. Repurposing the Veterinary Antiprotozoal Drug Ronidazole for the Treatment of Clostridioides difficile Infection. Int J Antimicrob Agents. 2020 Dec;56(6):106188. doi: 10.1016/j.ijantimicag.2020.106188. Epub 2020 Oct 9. PMID: 33045352; PMCID: PMC7704610. 2. Papich MG, Levine DN, Gookin JL, Davidson GS, Stagner WC, Hayes RB. Ronidazole pharmacokinetics in cats following delivery of a delayed-release guar gum formulation. J Vet Pharmacol Ther. 2013 Aug;36(4):399-407. doi: 10.1111/jvp.12019. Epub 2012 Oct 30. PMID: 23106427.
In vitro protocol:
To be determined
In vivo protocol:
1. AbdelKhalek A, Seleem MN. Repurposing the Veterinary Antiprotozoal Drug Ronidazole for the Treatment of Clostridioides difficile Infection. Int J Antimicrob Agents. 2020 Dec;56(6):106188. doi: 10.1016/j.ijantimicag.2020.106188. Epub 2020 Oct 9. PMID: 33045352; PMCID: PMC7704610. 2. Papich MG, Levine DN, Gookin JL, Davidson GS, Stagner WC, Hayes RB. Ronidazole pharmacokinetics in cats following delivery of a delayed-release guar gum formulation. J Vet Pharmacol Ther. 2013 Aug;36(4):399-407. doi: 10.1111/jvp.12019. Epub 2012 Oct 30. PMID: 23106427.
1: Jiang B, Liu Q, Wang M, Yang M, Li F, Zhang L, Zhou J. Development of purity certified reference materials to establish metrological traceability for the measurement of nitroimidazoles in agricultural products. Anal Bioanal Chem. 2024 Sep 19. doi: 10.1007/s00216-024-05530-3. Epub ahead of print. PMID: 39297935. 2: Zhang J, Lei B, Qin M, Lei T, Yang G, Liu J, Liu Q, Yang DJ, Song SF, Yang Y. Regioselective N-Trideuteromethylation of Tautomeric Polyaza Heterocycles. J Org Chem. 2024 Jun 7;89(11):7780-7789. doi: 10.1021/acs.joc.4c00448. Epub 2024 May 16. PMID: 38752832. 3: Mulligan TS, Mumm JS. Selective Cell Ablation Using an Improved Prodrug- Converting Nitroreductase. Methods Mol Biol. 2024;2707:223-234. doi: 10.1007/978-1-0716-3401-1_15. PMID: 37668916. 4: Wang J, Liu J, Liu W, Guo Y, Wu Q, Wang Z, Yan H. Porphyrin-based hypercrosslinked polymers as sorbents for efficient extraction of nitroimidazoles from water, honey and chicken breast. J Chromatogr A. 2023 Aug 2;1702:464087. doi: 10.1016/j.chroma.2023.464087. Epub 2023 May 19. PMID: 37230054. 5: Chen Y, Li P, Chen T, Liu H, Wang P, Dai X, Zou Q. Ronidazole Is a Superior Prodrug to Metronidazole for Nitroreductase-Mediated Hepatocytes Ablation in Zebrafish Larvae. Zebrafish. 2023 Jun;20(3):95-102. doi: 10.1089/zeb.2022.0066. Epub 2023 May 25. PMID: 37229597. 6: Karuppaiah B, Jeyaraman A, Chen SM, Chavan PR, Karthik R, Shim JJ, Park SJ. Design and synthesis of nickel-doped cobalt molybdate microrods: An effective electrocatalyst for the determination of antibiotic drug ronidazole. Environ Res. 2023 Apr 1;222:115343. doi: 10.1016/j.envres.2023.115343. Epub 2023 Jan 22. PMID: 36696945. 7: Gómez-Muñoz MT, Gómez-Molinero MÁ, González F, Azami-Conesa I, Bailén M, García Piqueras M, Sansano-Maestre J. Avian Oropharyngeal Trichomonosis: Treatment, Failures and Alternatives, a Systematic Review. Microorganisms. 2022 Nov 19;10(11):2297. doi: 10.3390/microorganisms10112297. PMID: 36422367; PMCID: PMC9695476. 8: Feng J, Jiang H, Wang J, Jing Z, Zhang F, Tan T, He F, Jiang L, Li H, Chang S, Li T. [Simultaneous determination of 40 plant growth regulators, fungicides, insecticides, and antibiotics in bean sprouts by QuEChERS-high performance liquid chromatography-tandem mass spectrometry]. Se Pu. 2022 Sep;40(9):843-853. Chinese. doi: 10.3724/SP.J.1123.2021.12028. PMID: 36156631; PMCID: PMC9520376. 9: Kang J, Ma X, Wu Y, Pang C, Li S, Li J, Xiong Y, Luo J, Wang M, Xu Z. Ligand- variable metal clusters charge transfer in Ce-Por-MOF/AgNWs and their application in photoelectrochemical sensing of ronidazole. Mikrochim Acta. 2022 Sep 14;189(10):383. doi: 10.1007/s00604-022-05477-1. PMID: 36102974. 10: Liu Z, Wang J, Guo Y, Liu J, Wang J, Wang C, Wu Q, Wang Z. Amino- functionalized hypercrosslinked polymer as sorbent for effective extraction of nitroimidazoles from water, drink and honey samples. J Chromatogr A. 2022 Aug 2;1676:463206. doi: 10.1016/j.chroma.2022.463206. Epub 2022 Jun 9. PMID: 35709602. 11: Santos CAR, Melo JC, Sampaio LHTS, Ferari LC, Moura FBC, Souza FB, Kobayashi PE, Fonseca-Alves CE, Okamoto PTCG, Rahal SC, Melchert A. Simultaneous occurrence of inflammatory bowel disease and trichomonosis in a Maine coon cat. Can Vet J. 2022 Mar;63(3):281-284. PMID: 35237015; PMCID: PMC8842383. 12: Xu M, Wang J, Zhang L, Wang Q, Liu W, An Y, Hao L, Wang C, Wang Z, Wu Q. Construction of hydrophilic hypercrosslinked polymer based on natural kaempferol for highly effective extraction of 5-nitroimidazoles in environmental water, honey and fish samples. J Hazard Mater. 2022 May 5;429:128288. doi: 10.1016/j.jhazmat.2022.128288. Epub 2022 Jan 17. PMID: 35066223. 13: Moral-Rodríguez AI, Leyva-Ramos R, Mendoza-Mendoza E, Díaz-Flores PE, Carrales-Alvarado DH, Alexandre-Franco MF, Fernández-González C. Single adsorption of diclofenac and ronidazole from aqueous solution on commercial activated carbons: effect of chemical and textural properties. Environ Sci Pollut Res Int. 2023 Feb;30(10):25193-25204. doi: 10.1007/s11356-021-17466-7. Epub 2022 Jan 11. PMID: 35015236. 14: Rush GM, Šlapeta J. Evidence of self-resolution of feline trichomonosis in a pair of single household cats due to ronidazole-resistant Tritrichomonas foetus. Vet Parasitol. 2021 Dec;300:109609. doi: 10.1016/j.vetpar.2021.109609. Epub 2021 Oct 26. PMID: 34735847. 15: Lai S, Kumari A, Liu J, Zhang Y, Zhang W, Yen K, Xu J. Chemical screening reveals Ronidazole is a superior prodrug to Metronidazole for nitroreductase- induced cell ablation system in zebrafish larvae. J Genet Genomics. 2021 Dec;48(12):1081-1090. doi: 10.1016/j.jgg.2021.07.015. Epub 2021 Aug 16. PMID: 34411714. 16: Guo Y, Wang J, Hao L, Wu Q, Wang C, Wang Z. Triazine-triphenylphosphine based porous organic polymer as sorbent for solid phase extraction of nitroimidazoles from honey and water. J Chromatogr A. 2021 Jul 19;1649:462238. doi: 10.1016/j.chroma.2021.462238. Epub 2021 May 12. PMID: 34034109. 17: AbdelKhalek A, Seleem MN. Repurposing the Veterinary Antiprotozoal Drug Ronidazole for the Treatment of Clostridioides difficile Infection. Int J Antimicrob Agents. 2020 Dec;56(6):106188. doi: 10.1016/j.ijantimicag.2020.106188. Epub 2020 Oct 9. PMID: 33045352; PMCID: PMC7704610. 18: Leelanupat A, Kamyingkird K, Chimnoi W, Nimsuphan B. Prevalence of Tritrichomonas foetus infection in cats in Bangkok metropolitan area and in vitro drug sensitivity testing. Vet Parasitol Reg Stud Reports. 2020 Jul;21:100440. doi: 10.1016/j.vprsr.2020.100440. Epub 2020 Jul 23. PMID: 32862898. 19: Nie J, Yan S, Lian L, Sharma VK, Song W. Development of fluorescence surrogates to predict the ferrate(VI) oxidation of pharmaceuticals in wastewater effluents. Water Res. 2020 Oct 15;185:116256. doi: 10.1016/j.watres.2020.116256. Epub 2020 Jul 31. PMID: 32768661. 20: Reuschel M, Pantchev N, Vrhovec MG, Jung A, Gerhauser I, Sannella AR, Cacciò SM, Legler M. Occurrence and Molecular Typing of Giardia psittaci in Parakeets in Germany-A Case Study. Avian Dis. 2020 Jun;64(2):228-233. doi: 10.1637/0005-2086-64.2.228. PMID: 32550625.