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MedKoo Cat#: 576364 | Name: Velnacrine maleate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Velnacrine maleate is an hydroxylated derivative of the acetylcholinesterase inhibitor tacrine.

Chemical Structure

Velnacrine maleate
Velnacrine maleate
CAS#118909-22-1

Theoretical Analysis

MedKoo Cat#: 576364

Name: Velnacrine maleate

CAS#: 118909-22-1

Chemical Formula: C17H18N2O5

Exact Mass: 330.1216

Molecular Weight: 330.34

Elemental Analysis: C, 61.81; H, 5.49; N, 8.48; O, 24.22

Price and Availability

Size Price Availability Quantity
250mg USD 400.00 2 Weeks
1g USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
HP 029 maleate; HP029 maleate; HP-029 maleate; Mentane; P83 6029A; Velnacrine maleate
IUPAC/Chemical Name
1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, (+-)-, (Z)-2-butenedioate (1:1) (salt)
InChi Key
NEEKVKZFYBQFGT-BTJKTKAUSA-N
InChi Code
InChI=1S/C13H14N2O.C4H4O4/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13;5-3(6)1-2-4(7)8/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code
Nc1c2C(O)CCCc2nc3ccccc13.OC(=O)\C=C/C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 330.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dembitsky VM, Dzhemileva L, Gloriozova T, D'yakonov V. Natural and synthetic drugs used for the treatment of the dementia. Biochem Biophys Res Commun. 2020 Apr 9;524(3):772-783. doi: 10.1016/j.bbrc.2020.01.123. Epub 2020 Feb 7. PMID: 32037088. 2: Sahoo AK, Dandapat J, Dash UC, Kanhar S. Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease. J Ethnopharmacol. 2018 Apr 6;215:42-73. doi: 10.1016/j.jep.2017.12.015. Epub 2017 Dec 14. PMID: 29248451. 3: Silva-Herdade AS, Saldanha C. Effects of acetylcholine on an animal mode of inflammation. Clin Hemorheol Microcirc. 2013;53(1-2):209-16. doi: 10.3233/CH-121646. PMID: 23187452. 4: Qian S, Wo SK, Zuo Z. Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats. J Pharm Biomed Anal. 2012 Mar 5;61:57-63. doi: 10.1016/j.jpba.2011.11.025. Epub 2011 Dec 3. PMID: 22196801. 5: Carvalho FA, de Almeida JP, Freitas-Santos T, Saldanha C. Modulation of erythrocyte acetylcholinesterase activity and its association with G protein- band 3 interactions. J Membr Biol. 2009 Mar;228(2):89-97. doi: 10.1007/s00232-009-9162-8. Epub 2009 Mar 18. PMID: 19294450. 6: Lopes de Almeida JP, Carvalho FA, Silva-Herdade AS, Santos-Freitas T, Saldanha C. Redox thiol status plays a central role in the mobilization and metabolism of nitric oxide in human red blood cells. Cell Biol Int. 2009 Mar;33(3):268-75. doi: 10.1016/j.cellbi.2008.11.012. Epub 2008 Dec 11. PMID: 19101643. 7: Carvalho FA, Almeida JP, Fernandes IO, Freitas-Santos T, Saldanha C. Non- neuronal cholinergic system and signal transduction pathways mediated by band 3 in red blood cells. Clin Hemorheol Microcirc. 2008;40(3):207-27. PMID: 19029645. 8: Almeida JP, Carvalho FA, Freitas T, Saldanha C. Modulation of hemorheological parameters by the erythrocyte redox thiol status. Clin Hemorheol Microcirc. 2008;40(2):99-111. PMID: 19029635. 9: de Oliveira S, Silva-Herdade AS, Saldanha C. Modulation of erythrocyte deformability by PKC activity. Clin Hemorheol Microcirc. 2008;39(1-4):363-73. PMID: 18503146. 10: Silva AS, Saldanha C, Martins e Silva J. Effects of velnacrine maleate in the leukocyte-endothelial cell interactions in rat cremaster microcirculatory network. Clin Hemorheol Microcirc. 2007;36(3):235-46. PMID: 17361025. 11: Sung JH, Hong SS, Ahn SH, Li H, Seo SY, Park CH, Park BS, Chung SJ. Mechanism for increased bioavailability of tacrine in fasted rats. J Pharm Pharmacol. 2006 May;58(5):643-9. doi: 10.1211/jpp.58.5.0009. PMID: 16640833. 12: Carvalho FA, Mesquita R, Martins-Silva J, Saldanha C. Acetylcholine and choline effects on erythrocyte nitrite and nitrate levels. J Appl Toxicol. 2004 Nov-Dec;24(6):419-27. doi: 10.1002/jat.993. PMID: 15551380. 13: Carvalho FA, Martins-Silva J, Saldanha C. Amperometric measurements of nitric oxide in erythrocytes. Biosens Bioelectron. 2004 Oct 15;20(3):505-8. doi: 10.1016/j.bios.2004.02.015. PMID: 15494232. 14: Jinghui L, Yingbao Y, Yongcheng L, Zhiliang C, Xiongyu W. [Effects of metabolites of mangrove fungus Xylaria sp. from South China Sea Coast on the activity of acetylcholinesterase in vitro]. Zhong Yao Cai. 2004 Apr;27(4):261-4. Chinese. PMID: 15307683. 15: Birks J, Wilcock GG. Velnacrine for Alzheimer's disease. Cochrane Database Syst Rev. 2004;(2):CD004748. doi: 10.1002/14651858.CD004748. PMID: 15106259. 16: Aparicio I, Callejón M, Bello MA, Jiménez JC, Guiraúm A. Spectrofluorimetric determination of velnacrine in human serum and urine. Farmaco. 2003 Dec;58(12):1257-61. doi: 10.1016/j.farmac.2003.07.007. PMID: 14630236. 17: Tabarrini O, Cecchetti V, Temperini A, Filipponi E, Lamperti MG, Fravolini A. Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease. Bioorg Med Chem. 2001 Nov;9(11):2921-8. doi: 10.1016/s0968-0896(01)00171-7. PMID: 11597473. 18: Schütz H, Ahrens B, Erdmann F, Weiler G. Nachweis des Cholinesterasehemmers Tacrin und seiner Hauptmetaboliten [Detection of the cholinesterase inhibitor tacrine and its main metabolites]. Arch Kriminol. 2001 May-Jun;207(5-6):154-61. German. PMID: 11508052. 19: Aparicio I, Callejón M, Jiménez JC, Bello MA, Guiraúm A. Electrochemical oxidation at carbon paste electrode of tacrine and 1-hydroxytacrine and differential pulse voltammetric determination of tacrine in pharmaceuticals and human urine. Analyst. 2000 Nov;125(11):2016-9. doi: 10.1039/b005874m. PMID: 11193091. 20: Nordberg A. PET studies and cholinergic therapy in Alzheimer's disease. Rev Neurol (Paris). 1999;155 Suppl 4:S53-63. PMID: 10637939.

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