Synonym
Almasilate; Malinal; Simagel; Dianeusine
IUPAC/Chemical Name
Magnesium aluminosilicate (MgAl2Si2O8) hydrate
InChi Key
HZVVJJIYJKGMFL-UHFFFAOYSA-N
InChi Code
InChI=1S/2Al.Mg.2H2O3Si.H2O/c;;;2*1-4(2)3;/h;;;2*1-2H;1H2/q2*+3;+2;;;
SMILES Code
O[Si](O)=O.O[Si](O)=O.O.[Mg+2].[Al+3].[Al+3]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
252.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Magaldrate and almasilate--complex buffering antacids. Drug Ther Bull. 1985 May 20;23(10):39-40. PMID: 3888581.
2: Rhodes J, Hughes HB. An in-vivo study of the buffering effect of almasilate in eight volunteers. Br J Clin Pract. 1984 Nov-Dec;38(11-12):412-3. PMID: 6529544.
3: Zeman J, Vetchý D, Pavloková S, Franc A, Pitschmann V, Dominik M, Urbanová M, Šeděnková I. Tubes for detection of cholinesterase inhibitors-Unique effects of Neusilin on the stability of butyrylcholinesterase-impregnated carriers. Enzyme Microb Technol. 2019 Sep;128:26-33. doi: 10.1016/j.enzmictec.2019.05.002. Epub 2019 May 6. PMID: 31186107.
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5: Rongthong T, Sungthongjeen S, Siepmann F, Siepmann J, Pongjanyakul T. Eudragit RL-based film coatings: How to minimize sticking and adjust drug release using MAS. Eur J Pharm Biopharm. 2020 Mar;148:126-133. doi: 10.1016/j.ejpb.2020.01.011. Epub 2020 Jan 23. PMID: 31982576.
6: Na YG, Byeon JJ, Wang M, Huh HW, Kim MK, Bang KH, Han MG, Lee HK, Cho CW. Statistical approach for solidifying ticagrelor loaded self-microemulsifying drug delivery system with enhanced dissolution and oral bioavailability. Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109980. doi: 10.1016/j.msec.2019.109980. Epub 2019 Jul 16. PMID: 31500011.
7: Zeman J, Vetchý D, Pavloková S, Franc A, Pitschmann V. Unique coated neusilin pellets with a more distinct and fast visual detection of nerve agents and other cholinesterase inhibitors. J Pharm Biomed Anal. 2020 Feb 5;179:113004. doi: 10.1016/j.jpba.2019.113004. Epub 2019 Nov 23. PMID: 31791835.
8: Kajthunyakarn W, Sakloetsakun D, Pongjanyakul T. Sodium caseinate-magnesium aluminum silicate nanocomposite films for modified-release tablets. Mater Sci Eng C Mater Biol Appl. 2018 Nov 1;92:827-839. doi: 10.1016/j.msec.2018.07.040. Epub 2018 Jul 19. PMID: 30184812.
9: Joyce P, Dening TJ, Meola TR, Gustafsson H, Kovalainen M, Prestidge CA. Nanostructured clay particles supplement orlistat action in inhibiting lipid digestion: An in vitro evaluation for the treatment of obesity. Eur J Pharm Sci. 2019 Jul 1;135:1-11. doi: 10.1016/j.ejps.2019.05.001. Epub 2019 May 5. PMID: 31067495.
10: Singh D, Singh AP, Singh D, Kesavan AK, Arora S, Tiwary AK, Bedi N. Enhanced oral bioavailability and anti-diabetic activity of canagliflozin through a spray dried lipid based oral delivery: a novel paradigm. Daru. 2020 Jun;28(1):191-208. doi: 10.1007/s40199-020-00330-3. Epub 2020 Feb 7. PMID: 32034683; PMCID: PMC7214577.
