Amycolatopsin A is a macrolide polyketide originally isolated from Amycolatopsis that has antimycobacterial and anticancer activities. It is active against M. bovis and M. tuberculosis (IC50s = 0.4 and 4.4 µM, respectively) but not B. subtilis, S. aureus, E. coli, or P. aeruginosa (IC50s = >30 µM for all). Amycolatopsin A is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 0.08 and 1.2 µM, respectively).
MedKoo Cat#: 464357
Name: Amycolatopsin A
CAS#: 2209112-96-7
Chemical Formula: C60H98O23
Exact Mass: 1186.6499
Molecular Weight: 1187.42
Elemental Analysis: C, 60.69; H, 8.32; O, 30.99
The following data is based on the product molecular weight 1,187.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
