Synonym
Noracetildenafil; Demethylhongdenafil;
IUPAC/Chemical Name
5-(2-ethoxy-5-(2-(4-methylpiperazin-1-yl)acetyl)phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
InChi Key
BEAXWKCHSPVXQB-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H32N6O3/c1-5-7-18-21-22(29(4)27-18)24(32)26-23(25-21)17-14-16(8-9-20(17)33-6-2)19(31)15-30-12-10-28(3)11-13-30/h8-9,14H,5-7,10-13,15H2,1-4H3,(H,25,26,32)
SMILES Code
O=C1N=C(NC2=C1N(N=C2CCC)C)C3=C(C=CC(C(CN4CCN(C)CC4)=O)=C3)OCC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Nor-Acetildenafil is an Acetildenafil derivative. Acetildenafil is a synthetic agent which acts as a phosphodiesterase inhibitor.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
452.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Doi T, Takahashi K, Yamazaki M, Asada A, Takeda A, Kiyota K, Tagami T, Sawabe Y, Yamano T. Characterization of a new illicit phosphodiesterase-type-5 inhibitor identified in the softgel shell of a dietary supplement. J Pharm Biomed Anal. 2018 Nov 30;161:61-65. doi: 10.1016/j.jpba.2018.08.031. Epub 2018 Aug 18. PMID: 30145450.
2: Hu T, Qu X, Kang M, Song Q, Yang L, Zhao Y, Zhang D. [Rapid screening and confirmation of illegally added anti- impotence preparations in health care products by high performance liquid chromatography-high resolution mass spectrometry]. Se Pu. 2015 Aug;33(8):897-901. Chinese. doi: 10.3724/sp.j.1123.2015.03020. PMID: 26749869.
3: Shi F, Guo C, Gong L, Li J, Dong P, Zhang J, Cui P, Jiang S, Zhao Y, Zeng S. Application of a high resolution benchtop quadrupole-Orbitrap mass spectrometry for the rapid screening, confirmation and quantification of illegal adulterated phosphodiesterase-5 inhibitors in herbal medicines and dietary supplements. J Chromatogr A. 2014 May 30;1344:91-8. doi: 10.1016/j.chroma.2013.12.030. Epub 2013 Dec 17. PMID: 24377735.
4: Reepmeyer JC, Woodruff JT. Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement. J Pharm Biomed Anal. 2007 Aug 15;44(4):887-93. doi: 10.1016/j.jpba.2007.04.011. Epub 2007 Apr 18. PMID: 17532168.
