MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 464340 | Name: Methocarbamol-d5
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methocarbamol-d5 is intended for use as an internal standard for the quantification of methocarbamol by GC- or LC-MS. Methocarbamol is an orally bioavailable skeletal muscle relaxant. In vivo, methocarbamol inhibits the ability of mice to remain on a vertical ladder for 1 minute (ED50 = 15 mg/kg) and decreases forelimb grip strength by 35.9% when administered at a dose of 500 mg/kg. It abolishes femoral nerve-stimulated polysynaptic reflex contractions of the cat tibialis anterior muscle and prolongs the mean refractory period of directly or indirectly stimulated skeletal muscle when administered at a dose of 200 mg/kg. Methocarbamol also selectively inhibits human carbonic anhydrase (CA) isoform I over CAII (IC50s = 70 and ~80,000 μM, respectively). Formulations containing methocarbamol have been used to treat skeletal muscle spasms.

Chemical Structure

Methocarbamol-d5
Methocarbamol-d5
CAS#1189699-70-4

Theoretical Analysis

MedKoo Cat#: 464340

Name: Methocarbamol-d5

CAS#: 1189699-70-4

Chemical Formula: C11H10D5NO5

Exact Mass: 246.1264

Molecular Weight: 246.27

Elemental Analysis: C, 53.65; H, 8.18; N, 5.69; O, 32.48

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Methocarbamol-d5; Methocarbamol d5; AHR 85-d5; AHR85-d5; AHR-85-d5; Guaiacol Glyceryl Ether Carbamate-d5; Guaiphenesin Carbamate-d5;
IUPAC/Chemical Name
2-hydroxy-3-(2-methoxyphenoxy)propyl-1,1,2,3,3-d5 carbamate
InChi Key
GNXFOGHNGIVQEH-RORPNYJOSA-N
InChi Code
InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)/i6D2,7D2,8D
SMILES Code
NC(OC([2H])(C([2H])(C([2H])(OC1=C(OC)C=CC=C1)[2H])O)[2H])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Methocarbamol-d5 is intended for use as an internal standard for the quantification of methocarbamol by GC- or LC-MS. Methocarbamol is an orally bioavailable skeletal muscle relaxant.
In vitro activity:
Methocarbamol, at 2 mM, decreased the decay of endplate currents, slowed the decay of endplate potentials and reduced tetanic force of soleus muscles. The drug reversibly inhibited current flow through muscular Nav 1.4 channels, while neuronal Nav 1.7 channels were unaffected. Reference: Muscle Nerve. 2021 Jan;63(1):141-150. https://pubmed.ncbi.nlm.nih.gov/33043468/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 246.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Zhang Y, Otto P, Qin L, Eiber N, Hashemolhosseini S, Kröger S, Brinkmeier H. Methocarbamol blocks muscular Nav 1.4 channels and decreases isometric force of mouse muscles. Muscle Nerve. 2021 Jan;63(1):141-150. doi: 10.1002/mus.27087. Epub 2020 Oct 27. PMID: 33043468. 2. Minai-Tehrani D, Toofani S, Yazdi F, Minai-Tehrani A, Mollasalehi H, Bakhtiari Ziabari K. Inhibition of pseudoperoxiadse activity of human red blood cell hemoglobin by methocarbamol. Int J Biol Macromol. 2017 Jan;94(Pt B):788-792. doi: 10.1016/j.ijbiomac.2016.09.049. Epub 2016 Sep 16. PMID: 27645932.
In vitro protocol:
1. Zhang Y, Otto P, Qin L, Eiber N, Hashemolhosseini S, Kröger S, Brinkmeier H. Methocarbamol blocks muscular Nav 1.4 channels and decreases isometric force of mouse muscles. Muscle Nerve. 2021 Jan;63(1):141-150. doi: 10.1002/mus.27087. Epub 2020 Oct 27. PMID: 33043468. 2. Minai-Tehrani D, Toofani S, Yazdi F, Minai-Tehrani A, Mollasalehi H, Bakhtiari Ziabari K. Inhibition of pseudoperoxiadse activity of human red blood cell hemoglobin by methocarbamol. Int J Biol Macromol. 2017 Jan;94(Pt B):788-792. doi: 10.1016/j.ijbiomac.2016.09.049. Epub 2016 Sep 16. PMID: 27645932.
In vivo protocol:
TBD
1: Gosset A, Wiest L, Fildier A, Libert C, Giroud B, Hammada M, Hervé M, Sibeud E, Vulliet E, Polomé P, Perrodin Y. Ecotoxicological risk assessment of contaminants of emerging concern identified by "suspect screening" from urban wastewater treatment plant effluents at a territorial scale. Sci Total Environ. 2021 Mar 8;778:146275. doi: 10.1016/j.scitotenv.2021.146275. Epub ahead of print. PMID: 33714835. 2: Heshmatifar N, Salari M, Rad M, Afshari Saleh T, Borzoee F, Rastaghi S. A New Approach on the pain management of intramuscular injection: A Triple-Blind Randomized Clinical Trial. Pain Manag Nurs. 2021 Mar 10:S1524-9042(21)00025-4. doi: 10.1016/j.pmn.2021.01.010. Epub ahead of print. PMID: 33714700. 3: Li Y, Delcher C, Reisfield GM, Wei YJ, Brown JD, Winterstein AG. Utilization patterns of skeletal muscle relaxants among commercially insured adults in the United States from 2006 to 2018. Pain Med. 2021 Mar 4:pnab088. doi: 10.1093/pm/pnab088. Epub ahead of print. PMID: 33690860. 4: Thurber MI, Doss G, Kory P, Tarula E, Sladky K. MANAGEMENT OF MEDICAL COMPLICATIONS ASSOCIATED WITH A PRESUMED TETANUS INFECTION IN A NORTHWEST BORNEAN ORANGUTAN (PONGO PYGMAEUS PYGMAEUS). J Zoo Wildl Med. 2021 Jan;51(4):1072-1076. doi: 10.1638/2020-0120. PMID: 33480593. 5: Güzel R, Ertekin ZC, Dinç E. A New Application of PARAFAC Model to UPLC Dataset for the Quantitative Resolution of a Tri-Component Drug Mixture. J Chromatogr Sci. 2021 Mar 19;59(4):361-370. doi: 10.1093/chromsci/bmaa119. PMID: 33454729. 6: Kalokhe S, Nalwade S, Patil P, Raskar P. Development and Validation of a Stability-Indicating High-Performance Liquid Chromatographic Method for the Quantification of Methocarbamol and Its Impurities in Pharmaceutical Dosage Forms. J Chromatogr Sci. 2021 Jan 5:bmaa125. doi: 10.1093/chromsci/bmaa125. Epub ahead of print. PMID: 33395699. 7: Sibrack J, Hammer R. Methocarbamol. 2020 Dec 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 33351427. 8: Deloney LP, Smith Condeni M, Carter C, Privette A, Leon S, Eriksson EA. Efficacy of Methocarbamol for Acute Pain Management in Young Adults With Traumatic Rib Fractures. Ann Pharmacother. 2020 Oct 12:1060028020964796. doi: 10.1177/1060028020964796. Epub ahead of print. PMID: 33045839. 9: Zhang Y, Otto P, Qin L, Eiber N, Hashemolhosseini S, Kröger S, Brinkmeier H. Methocarbamol blocks muscular Nav 1.4 channels and decreases isometric force of mouse muscles. Muscle Nerve. 2021 Jan;63(1):141-150. doi: 10.1002/mus.27087. Epub 2020 Oct 27. PMID: 33043468. 10: Ye J, Myung K, Packiasabapathy S, Yu JS, Jacobson JE, Whittaker SC, Castelluccio P, Drayton Jackson M, Sadhasivam S. Methadone-based Multimodal Analgesia Provides the Best-in-class Acute Surgical Pain Control and Functional Outcomes With Lower Opioid Use Following Major Posterior Fusion Surgery in Adolescents With Idiopathic Scoliosis. Pediatr Qual Saf. 2020 Jul 27;5(4):e336. doi: 10.1097/pq9.0000000000000336. PMID: 32766507; PMCID: PMC7392616. 11: Schwagerus L, Dörner K, Bender S, Müller K, Bitterlich N, Rothkötter HJ, Günther O. Myofaszial bedingte chronische Unterbauchschmerzen bei Frauen : Eine retrospektive Auswertung der Auswirkungen einer spezifischen Diagnostik und Therapie [Myofascial chronic pelvic pain in women : A retrospective evaluation of the effects of specific diagnostics and therapy]. Schmerz. 2020 Oct;34(5):388-399. German. doi: 10.1007/s00482-020-00488-4. PMID: 32725502. 12: Kadado A, Slotkin S, Akioyamen NO, El-Alam A, North WT. Total Knee Arthroplasty: Opioid-Free Analgesia in a Patient with Opioid-Induced Hyperalgesia: A Case Report. JBJS Case Connect. 2020 Jul-Sep;10(3):e20.00024. doi: 10.2106/JBJS.CC.20.00024. PMID: 32618610. 13: Caan MP, Lim CT, Howard M. A Case of Catatonia in a Man With COVID-19. Psychosomatics. 2020 Sep-Oct;61(5):556-560. doi: 10.1016/j.psym.2020.05.021. Epub 2020 May 27. PMID: 32605766; PMCID: PMC7251411. 14: Shiri S, Alizadeh K, Abbasi N. A novel technique for simultaneous determination of drugs using magnetic nanoparticles based dispersive micro- solid-phase extraction in biological fluids and wastewaters. MethodsX. 2020 Jun 9;7:100952. doi: 10.1016/j.mex.2020.100952. PMID: 32596135; PMCID: PMC7306602. 15: Harris AB, Puvanesarajah V, Marrache M, Gottlich CP, Raad M, Skolasky RL, Njoku DB, Sponseller PD, Jain A. Opioid prescribing practices after posterior spinal arthrodesis for adolescent idiopathic scoliosis. Spine Deform. 2020 Oct;8(5):965-973. doi: 10.1007/s43390-020-00127-z. Epub 2020 May 6. Erratum in: Spine Deform. 2020 Jun 12;: PMID: 32378042. 16: Emrich OMD, Milachowski KA, Strohmeier M. Erratum zu: Methocarbamol bei akuten Rückenschmerzen. MMW Fortschr Med. 2019 Oct;161(Suppl 6):2. German. doi: 10.1007/s15006-019-0811-2. Erratum for: MMW Fortschr Med. 2015 Jul;157 Suppl 5:9-16. PMID: 31587171. 17: Ban VS, Bhoja R, McDonagh DL. Multimodal analgesia for craniotomy. Curr Opin Anaesthesiol. 2019 Oct;32(5):592-599. doi: 10.1097/ACO.0000000000000766. PMID: 31306155. 18: Sarmiento JM, Medina O, Do ASS, Farber S, Chu RM. Resection of Cervical Juxtacortical Chondroma and Circumferential Spinal Stabilization for Kyphotic Deformity. Cureus. 2019 Apr 22;11(4):e4523. doi: 10.7759/cureus.4523. PMID: 31259132; PMCID: PMC6590731. 19: Gangwani MK, Aziz M, Asif R, Ali SA. Green Urine And Altered Mental Status: A Case Of Intoxication. J Ayub Med Coll Abbottabad. 2019 Apr-Jun;31(2):278-281. PMID: 31094132. 20: Kriel HH, Yngve D. Elastomeric Pain Pumps for Scoliosis Surgery. Cureus. 2019 Feb 11;11(2):e4042. doi: 10.7759/cureus.4042. PMID: 31016070; PMCID: PMC6464437.