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MedKoo Cat#: 413647 | Name: MDL 73404

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDL 73404 is a hydrophilic cardioselective free radical scavenger; analog of alpha-tocopherol.

Chemical Structure

MDL 73404
MDL 73404
CAS#130573-32-9

Theoretical Analysis

MedKoo Cat#: 413647

Name: MDL 73404

CAS#: 130573-32-9

Chemical Formula: C25H37NO5S

Exact Mass: 463.2392

Molecular Weight: 463.63

Elemental Analysis: C, 64.77; H, 8.04; N, 3.02; O, 17.25; S, 6.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MDL 73404; DHHBE; Mdl73404; Mdl-73404
IUPAC/Chemical Name
3,4-Dihydro-6-hydroxy-N,N,N,2,5,7,8-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate
InChi Key
OCKUZZXXLQTSON-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H29NO2.C7H8O3S/c1-12-13(2)17-15(14(3)16(12)20)8-9-18(4,21-17)10-11-19(5,6)7;1-6-2-4-7(5-3-6)11(8,9)10/h8-11H2,1-7H3;2-5H,1H3,(H,8,9,10)
SMILES Code
CC1=C2C(CCC(CC[N+](C)(C)C)(C)O2)=C(C)C(O)=C1C.O=S(C3=CC=C(C)C=C3)([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 463.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lukovic L, Petty MA, Bolkenius FN, Grisar JM, Dow J, De Jong W. Protection of infarcted, chronically reperfused hearts by an alpha-tocopherol analogue. Eur J Pharmacol. 1993 Mar 16;233(1):63-70. doi: 10.1016/0014-2999(93)90349-m. PMID: 8472749. 2: Petty MA, Grisar JM, De Jong W. Protective effects of an alpha-tocopherol analogue against myocardial reperfusion injury in rats. Eur J Pharmacol. 1992 Jan 7;210(1):85-90. doi: 10.1016/0014-2999(92)90655-n. PMID: 1601050. 3: Barclay LR, Vinqvist MR. Membrane peroxidation: inhibiting effects of water- soluble antioxidants on phospholipids of different charge types. Free Radic Biol Med. 1994 Jun;16(6):779-88. doi: 10.1016/0891-5849(94)90193-7. PMID: 8070681. 4: Murthy S, Hui-Qi Q, Sakai T, Depace DE, Fondacaro JD. Ischemia/reperfusion injury in the rat colon. Inflammation. 1997 Apr;21(2):173-90. doi: 10.1023/a:1027318203971. PMID: 9187961. 5: Snircová M, Kucharská J, Herichová I, Bada V, Gvozdjáková A. Vplyv analógu alfatokoferolu MDL 73,404 na bioenergetiku myokardu [The effect of an alpha- tocopherol analog, MDL 73404, on myocardial bioenergetics]. Bratisl Lek Listy. 1996 Jun;97(6):355-9. Slovak. PMID: 8769068. 6: Grisar JM, Petty MA, Bolkenius FN, Dow J, Wagner J, Wagner ER, Haegele KD, De Jong W. A cardioselective, hydrophilic N,N,N-trimethylethanaminium alpha- tocopherol analogue that reduces myocardial infarct size. J Med Chem. 1991 Jan;34(1):257-60. doi: 10.1021/jm00105a040. PMID: 1992125. 7: Núñez-Delicado E, Sojo M, García-Carmona F, Sánchez-Ferrer A. Anomalous oxidation of MDL 73,404 by horseradish peroxidase. Int J Biochem Cell Biol. 2003 Feb;35(2):183-91. doi: 10.1016/s1357-2725(02)00168-1. PMID: 12479868. 8: Kuo BS, Mathews BS, Stuhler JD, Carrel BK, Ho J, Rose JQ. Disposition and cardioselectivity of MDL 74,405, a vitamin E-like free radical scavenger, in rats and dogs after intravenous infusion. Drug Metab Dispos. 1995 Jul;23(7):757-64. PMID: 7587965. 9: Zughaib ME, Tang XL, Schleman M, Jeroudi MO, Bolli R. Beneficial effects of MDL 74,405, a cardioselective water soluble alpha tocopherol analogue, on the recovery of function of stunned myocardium in intact dogs. Cardiovasc Res. 1994 Feb;28(2):235-41. doi: 10.1093/cvr/28.2.235. PMID: 8143306. 10: Tang XL, Kaur H, Sun JZ, Qiu Y, Park SW, Schleman M, Halliwell B, Bolli R. Effect of the hydrophilic alpha-tocopherol analog MDL 74,405 on detection of hydroxyl radicals in stunned myocardium in dogs. Am Heart J. 1995 Nov;130(5):940-8. doi: 10.1016/0002-8703(95)90192-2. PMID: 7484754.