CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio. It is active against P. falciparum when used at concentrations of 10 and 100 µM. CP21 inhibits production of prostaglandin I2 induced by epinephrine, arachidonic acid, or A23187 in isolated rat aortic rings with IC50 values of 1.3, 1.3, and 1.4 mM, respectively. It inhibits glutamate-induced oxytosis, as well as decreases iodoacetic acid-induced cytotoxicity in an in vitro model of ischemia, in HT22 mouse hippocampal cells (EC50s = 13 and 9.5 µM, respectively). CP21 (200 mg/kg) increases the excretion of iron, but not copper, zinc, calcium, or magnesium, in rabbits.
MedKoo Cat#: 464333
Name: CP21
CAS#: 30652-12-1
Chemical Formula: C8H11NO2
Exact Mass: 153.0790
Molecular Weight: 153.18
Elemental Analysis: C, 62.73; H, 7.24; N, 9.14; O, 20.89
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 1.0 | 0.00 | |
| DMSO | 1.0 | 0.00 | |
| Ethanol | 10.0 | 0.00 | |
| Ethanol:PBS (pH 7.2) (1:4) | 0.2 | 0.00 |
The following data is based on the product molecular weight 153.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
