MedKoo Cat#: 464280 | Name: GSK417651A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK417651A is a chemical compound which acts as a blocker of the TRPC family of calcium channels, with selectivity for the TRPC3 and TRPC6 subtypes. It has been used to investigate the role of TRPC3/6 channels in heart function.

Chemical Structure

GSK417651A
GSK417651A
CAS#736945-96-3

Theoretical Analysis

MedKoo Cat#: 464280

Name: GSK417651A

CAS#: 736945-96-3

Chemical Formula: C20H19N3O2S

Exact Mass: 365.1198

Molecular Weight: 365.45

Elemental Analysis: C, 65.73; H, 5.24; N, 11.50; O, 8.76; S, 8.77

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 600.00 2 Weeks
25mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
GSK417651A; GSK 417651A; GSK-417651A; TRPC3/6-IN-1
IUPAC/Chemical Name
(3,4-dihydroisoquinolin-2(1H)-yl)(2-((4-methoxyphenyl)amino)thiazol-4-yl)methanone
InChi Key
NTXBDULODNTCKP-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22)
SMILES Code
O=C(C1=CSC(NC2=CC=C(OC)C=C2)=N1)N3CCC4=CC=CC=C4C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 365.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Al-Shammari H, Latif N, Sarathchandra P, McCormack A, Rog-Zielinska EA, Raja S, Kohl P, Yacoub MH, Peyronnet R, Chester AH. Expression and function of mechanosensitive ion channels in human valve interstitial cells. PLoS One. 2020 Oct 15;15(10):e0240532. doi: 10.1371/journal.pone.0240532. PMID: 33057457; PMCID: PMC7561104.